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Open problems in Image segmentation

Lack of benchmarks for agentic evidence-seeking in medical imaging1 paper raises it · 1 addresses it
Current benchmarks assess reasoning over preselected evidence rather than the ability to autonomously seek and integrate longitudinal imaging and clinical records.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Scaling parameter-efficient fine-tuning for large medical models1 paper raises it · 1 addresses it
Neural data is costly and limited, making full fine-tuning or training from scratch impractical for large models in medical tasks like brain encoding.
- Scaling Parameter-Efficient Fine-Tuning for Brain Encodingraises · addresses
Generating coherent gigapixel whole-slide images1 paper raises it · 1 addresses it
Existing histopathology generative models operate at patch scale, while clinical supervision and diagnoses operate at whole-slide level, creating a mismatch.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Anatomically unsupported detail in generative super-resolution for CT1 paper raises it · 1 addresses it
Generative super-resolution can produce visually plausible but anatomically incorrect vascular structures in CT images.
- VascuSR: Iterative Anatomy-Aware Diffusion for CT Super-Resolutionraises · addresses
Frozen models unable to learn from deployment experience1 paper raises it · 1 addresses it
Deployed medical AI models are typically frozen, preventing them from adapting to new clinical evidence or updated guidelines.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses

Named by an AI from these papers' abstracts.

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Topics in this field

image segmentation · volumetric · medical image395 papers54 this week
clinical reasoning · question answering · language models202 papers35 this week
radiology report generation · medical vision language · vision language models114 papers25 this week
patient history · clinical data · health records105 papers23 this week
eeg foundation models · electroencephalography eeg · eeg foundation150 papers20 this week
electrocardiogram ecg · electrocardiogram · ecgs141 papers13 this week

Topics in this field

Active contributors · 90 days

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Activity · 12 weeks

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All papers in Research

arXiv cs.AIOct 8
Social Pain Disrupts Emotion-Action Brain-State Dynamics in Adolescents with Non-Suicidal Self-Injury
Ying Xu, Xiaojun Liang, Li Zhang, Yixuan Yuan, Gan Huang +2
Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear. We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions. A model integrating disease-specific, domain-adversarial, consistency, and contrastive learning captures higher-order dependencies in microstate sequences. Social pain yields the strongest NSSI discrimination, with 68.55% accuracy, outperforming the best baseline by 8.94% points. Model interpretation and conventional microstate analyses reveal weakened bidirectional transitions between MS3 and MS5 in DN+ adolescents during social pain. Source reconstruction associates MS3 with emotional/interoceptive processing and MS5 with action preparation, suggesting disrupted emotion-action coupling. Time-resolved analyses show greater early-to-middle action-state recruitment and later…
PDF arXiv
arXiv cs.LGOct 8
ActiveMedAgent: Cost-Aware Trajectory Learning for Multimodal Medical Diagnosis
Weiwei Ma, Xiaobing Yu, Peijie Qiu, Jin Yang, Zhaoqi An +3
Clinical diagnosis is inherently sequential: clinicians escalate from cheap to costly tests only when additional evidence is expected to resolve diagnostic uncertainty. We present ActiveMedAgent, a framework that brings this cost-aware sequential logic to multimodal medical AI. Given a frozen, API-accessed vision-language model, ActiveMedAgent tracks probability distributions over candidate diagnoses and scores each acquisition by its per-step diagnostic utility minus cost. A lightweight MLP controller is then trained offline on these scored trajectories, learning when to request additional evidence and when to commit. Across three commonly used benchmarks, trajectory-based policy learning consistently outperforms both unguided acquisition and full-modality baselines. Notably, we identify an information overload effect. In 175 cases, the agent produces a correct diagnosis with fewer channels while the full-modality baseline fails, showing that learning what to omit can be as important as learning what to acquire.
PDF arXiv
arXiv cs.CVOct 8
Skeleton-Guided Progressive Test-Time Adaptation for Thin Curvilinear Structures
Boa Jang, JunGyu Lee, Gwanho Lee, Jinwook Choi, Young-Gon Kim
Accurate segmentation of thin curvilinear structures is vital for various real-world applications, from vessel analysis to road extraction. Yet their intricate geometry makes even minor pixel-wise errors enough to break the global topology, and this structural fragility turns severe domain shifts into catastrophic failures. The difficulty is most acute under cross-modality gaps, where the imaging process itself differs fundamentally between source and target. While test-time adaptation (TTA) offers a practical source-free remedy, existing methods adapt feature statistics and confidence, neither of which constrains connectivity, and thus degrade under such extreme gaps. To address this, we propose Skeleton-Guided Progressive Test-Time Adaptation (SGP-TTA). Progressive Batch Normalization (ProgBN) shifts normalization from frozen source statistics toward current target estimates under a sample-count schedule, so that the source-target balance follows the stage of adaptation rather than a fixed coefficient. Consensus Skeleton Recall (CSR) then derives a structural target from geometrically aligned multi-view predictions and updates only the BN affine parameters to preserve connected…
PDF arXiv
arXiv cs.CVOct 8
Contrast Enhancement or Noise Reduction? On Improving Cervical Cancer Classification
Ach Khozaimi, Ulfatun Nahdhiyah
Purpose: Cervical cancer is one of the leading causes of mortality worldwide. Deep learning has shown promising performance in medical image classification. The influence of image preprocessing algorithms on classification performance remains insufficiently investigated in the literature. This research aims to evaluate the impact of image preprocessing algorithms on the performance of CNNs for Pap smear image classification. Methods: Three CNN architectures (ResNet-34, MobileNet-V2, and DenseNet-121) were trained and evaluated using the SIPaKMeD dataset. Two preprocessing algorithms were applied: the PMD filter for noise reduction and CLAHE for contrast enhancement. The model performance was assessed using a confusion matrix. Results: Preprocessing improved the classification performance of all models. CLAHE significantly increased the accuracy of ResNet-34 from 76.73% to 84.16% and DenseNet-121 from 76.73% to 84.16%. The PMD filter yielded limited improvement and slightly reduced the MobileNet-V2 performance. Novelty: This research provides a systematic comparison of contrast enhancement and noise reduction techniques across CNN architectures. This research demonstrates that…
PDF arXiv
arXiv cs.CLCodeOct 8▲ 3
Clinician use of language models diverges from how the models are evaluated
Krithik Vishwanath, Haitong Lin, Anton Alyakin, Jin Vivian Lee, D. Brock Hewitt +17
Large language model (LLM) assistants are being deployed to clinicians across health systems, and judgments about their readiness rest largely on benchmark scores, most of them derived from examination questions or curated cases. A benchmark predicts performance in deployment only to the extent that its items resemble real use, yet whether benchmarks reflect the work these systems receive has rarely been measured. Here we analyze 127,833 queries sent by 6,342 physicians, advanced practice providers and nurses in 35 specialties to an institutional assistant during an eight-month roll-out. We characterize each query with RCQ-Map, a clinician-validated framework grounded in taxonomies of clinical questions and of LLM evaluation, which records its task, intent, answerability, missing information and potential harm. Documentation and administration (36.2%) and knowledge retrieval (28.9%) made up nearly two-thirds of use, and diagnosis 3.7%; more than a third of queries could not be answered well as posed. Applying RCQ-Map to 58 public benchmarks drawn from major evaluation suites and frontier model reports, which we assemble into the Clinical AI Benchmark Atlas, showed that the median…
PDF arXiv Code
arXiv cs.LGOct 7
Similar Predictive Fit but Different Latent Dynamics: Characterizing Learned Dynamical Structure in Personalized Models of Brain Disorders
Rita Huan-Ting Peng, Nhat Bui
As AI models move toward clinical decision-making and personalized treatment, understanding \emph{what} a model learns is important beyond predictive accuracy alone. We investigate whether personalized latent dynamics reveal clinically associated differences even when predictive fit is similar. A lightweight CNN--Transformer EEG foundation model pretrained on the Temple University EEG Corpus (TUEG) extracts segment-level representations. Using the Temple University Epilepsy Corpus (TUEP), representations are mapped to a shared latent-state space, and sparse multinomial logistic transition distributions (mLTD) are fit independently to each subject to obtain personalized transition-dependency graphs $W_n$. Analyses include $n{=}198$ subjects (99 epilepsy / 99 non-epilepsy). At $k{=}4$, epilepsy subjects exhibit substantially denser learned dependency structure ($p{=}1.1\times10^{-7}$), with the same pattern at $k{=}6$ (19.90 vs. 13.46; $p{=}5.2\times10^{-5}$). Graph-derived features provide moderate group discrimination under 5-fold subject-wise cross-validation (AUROC 0.68 at $k{=}4$; 0.65 at $k{=}6$). In contrast, held-out log-likelihood is nearly identical between groups at…
PDF arXiv

Papers

Topics in this field

image segmentation · volumetric · medical image395 papers54 this week
clinical reasoning · question answering · language models202 papers35 this week
radiology report generation · medical vision language · vision language models114 papers25 this week
patient history · clinical data · health records105 papers23 this week
eeg foundation models · electroencephalography eeg · eeg foundation150 papers20 this week
electrocardiogram ecg · electrocardiogram · ecgs141 papers13 this week

Active contributors · 90 days

Activity · 12 weeks

Open problems in Image segmentation

Lack of benchmarks for agentic evidence-seeking in medical imaging1 paper raises it · 1 addresses it
Current benchmarks assess reasoning over preselected evidence rather than the ability to autonomously seek and integrate longitudinal imaging and clinical records.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Scaling parameter-efficient fine-tuning for large medical models1 paper raises it · 1 addresses it
Neural data is costly and limited, making full fine-tuning or training from scratch impractical for large models in medical tasks like brain encoding.
- Scaling Parameter-Efficient Fine-Tuning for Brain Encodingraises · addresses
Generating coherent gigapixel whole-slide images1 paper raises it · 1 addresses it
Existing histopathology generative models operate at patch scale, while clinical supervision and diagnoses operate at whole-slide level, creating a mismatch.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Anatomically unsupported detail in generative super-resolution for CT1 paper raises it · 1 addresses it
Generative super-resolution can produce visually plausible but anatomically incorrect vascular structures in CT images.
- VascuSR: Iterative Anatomy-Aware Diffusion for CT Super-Resolutionraises · addresses
Frozen models unable to learn from deployment experience1 paper raises it · 1 addresses it
Deployed medical AI models are typically frozen, preventing them from adapting to new clinical evidence or updated guidelines.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses

Named by an AI from these papers' abstracts.

Recent papers

All papers in Research

arXiv cs.AIOct 8
Social Pain Disrupts Emotion-Action Brain-State Dynamics in Adolescents with Non-Suicidal Self-Injury
Ying Xu, Xiaojun Liang, Li Zhang, Yixuan Yuan, Gan Huang +2
Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear. We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions. A model integrating disease-specific, domain-adversarial, consistency, and contrastive learning captures higher-order dependencies in microstate sequences. Social pain yields the strongest NSSI discrimination, with 68.55% accuracy, outperforming the best baseline by 8.94% points. Model interpretation and conventional microstate analyses reveal weakened bidirectional transitions between MS3 and MS5 in DN+ adolescents during social pain. Source reconstruction associates MS3 with emotional/interoceptive processing and MS5 with action preparation, suggesting disrupted emotion-action coupling. Time-resolved analyses show greater early-to-middle action-state recruitment and later…
PDF arXiv
arXiv cs.LGOct 8
ActiveMedAgent: Cost-Aware Trajectory Learning for Multimodal Medical Diagnosis
Weiwei Ma, Xiaobing Yu, Peijie Qiu, Jin Yang, Zhaoqi An +3
Clinical diagnosis is inherently sequential: clinicians escalate from cheap to costly tests only when additional evidence is expected to resolve diagnostic uncertainty. We present ActiveMedAgent, a framework that brings this cost-aware sequential logic to multimodal medical AI. Given a frozen, API-accessed vision-language model, ActiveMedAgent tracks probability distributions over candidate diagnoses and scores each acquisition by its per-step diagnostic utility minus cost. A lightweight MLP controller is then trained offline on these scored trajectories, learning when to request additional evidence and when to commit. Across three commonly used benchmarks, trajectory-based policy learning consistently outperforms both unguided acquisition and full-modality baselines. Notably, we identify an information overload effect. In 175 cases, the agent produces a correct diagnosis with fewer channels while the full-modality baseline fails, showing that learning what to omit can be as important as learning what to acquire.
PDF arXiv
arXiv cs.CVOct 8
Skeleton-Guided Progressive Test-Time Adaptation for Thin Curvilinear Structures
Boa Jang, JunGyu Lee, Gwanho Lee, Jinwook Choi, Young-Gon Kim
Accurate segmentation of thin curvilinear structures is vital for various real-world applications, from vessel analysis to road extraction. Yet their intricate geometry makes even minor pixel-wise errors enough to break the global topology, and this structural fragility turns severe domain shifts into catastrophic failures. The difficulty is most acute under cross-modality gaps, where the imaging process itself differs fundamentally between source and target. While test-time adaptation (TTA) offers a practical source-free remedy, existing methods adapt feature statistics and confidence, neither of which constrains connectivity, and thus degrade under such extreme gaps. To address this, we propose Skeleton-Guided Progressive Test-Time Adaptation (SGP-TTA). Progressive Batch Normalization (ProgBN) shifts normalization from frozen source statistics toward current target estimates under a sample-count schedule, so that the source-target balance follows the stage of adaptation rather than a fixed coefficient. Consensus Skeleton Recall (CSR) then derives a structural target from geometrically aligned multi-view predictions and updates only the BN affine parameters to preserve connected…
PDF arXiv
arXiv cs.CVOct 8
Contrast Enhancement or Noise Reduction? On Improving Cervical Cancer Classification
Ach Khozaimi, Ulfatun Nahdhiyah
Purpose: Cervical cancer is one of the leading causes of mortality worldwide. Deep learning has shown promising performance in medical image classification. The influence of image preprocessing algorithms on classification performance remains insufficiently investigated in the literature. This research aims to evaluate the impact of image preprocessing algorithms on the performance of CNNs for Pap smear image classification. Methods: Three CNN architectures (ResNet-34, MobileNet-V2, and DenseNet-121) were trained and evaluated using the SIPaKMeD dataset. Two preprocessing algorithms were applied: the PMD filter for noise reduction and CLAHE for contrast enhancement. The model performance was assessed using a confusion matrix. Results: Preprocessing improved the classification performance of all models. CLAHE significantly increased the accuracy of ResNet-34 from 76.73% to 84.16% and DenseNet-121 from 76.73% to 84.16%. The PMD filter yielded limited improvement and slightly reduced the MobileNet-V2 performance. Novelty: This research provides a systematic comparison of contrast enhancement and noise reduction techniques across CNN architectures. This research demonstrates that…
PDF arXiv
arXiv cs.CLCodeOct 8▲ 3
Clinician use of language models diverges from how the models are evaluated
Krithik Vishwanath, Haitong Lin, Anton Alyakin, Jin Vivian Lee, D. Brock Hewitt +17
Large language model (LLM) assistants are being deployed to clinicians across health systems, and judgments about their readiness rest largely on benchmark scores, most of them derived from examination questions or curated cases. A benchmark predicts performance in deployment only to the extent that its items resemble real use, yet whether benchmarks reflect the work these systems receive has rarely been measured. Here we analyze 127,833 queries sent by 6,342 physicians, advanced practice providers and nurses in 35 specialties to an institutional assistant during an eight-month roll-out. We characterize each query with RCQ-Map, a clinician-validated framework grounded in taxonomies of clinical questions and of LLM evaluation, which records its task, intent, answerability, missing information and potential harm. Documentation and administration (36.2%) and knowledge retrieval (28.9%) made up nearly two-thirds of use, and diagnosis 3.7%; more than a third of queries could not be answered well as posed. Applying RCQ-Map to 58 public benchmarks drawn from major evaluation suites and frontier model reports, which we assemble into the Clinical AI Benchmark Atlas, showed that the median…
PDF arXiv Code
arXiv cs.LGOct 7
Similar Predictive Fit but Different Latent Dynamics: Characterizing Learned Dynamical Structure in Personalized Models of Brain Disorders
Rita Huan-Ting Peng, Nhat Bui
As AI models move toward clinical decision-making and personalized treatment, understanding \emph{what} a model learns is important beyond predictive accuracy alone. We investigate whether personalized latent dynamics reveal clinically associated differences even when predictive fit is similar. A lightweight CNN--Transformer EEG foundation model pretrained on the Temple University EEG Corpus (TUEG) extracts segment-level representations. Using the Temple University Epilepsy Corpus (TUEP), representations are mapped to a shared latent-state space, and sparse multinomial logistic transition distributions (mLTD) are fit independently to each subject to obtain personalized transition-dependency graphs $W_n$. Analyses include $n{=}198$ subjects (99 epilepsy / 99 non-epilepsy). At $k{=}4$, epilepsy subjects exhibit substantially denser learned dependency structure ($p{=}1.1\times10^{-7}$), with the same pattern at $k{=}6$ (19.90 vs. 13.46; $p{=}5.2\times10^{-5}$). Graph-derived features provide moderate group discrimination under 5-fold subject-wise cross-validation (AUROC 0.68 at $k{=}4$; 0.65 at $k{=}6$). In contrast, held-out log-likelihood is nearly identical between groups at…
PDF arXiv

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