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Open problems in Image segmentation

Lack of benchmarks for real-world clinical deployment1 paper raises it · 0 address it
Current benchmarks do not reflect how clinicians actually use AI systems, limiting their predictive value for real-world performance.
- Clinician use of language models diverges from how the models are evaluatedraises
Handling gigapixel whole-slide images in segmentation1 paper raises it · 1 addresses it
Existing models operate at patch scale, but clinical supervision and labels are at the whole-slide level, creating a mismatch.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Temporal modeling of multimodal clinical trajectories1 paper raises it · 1 addresses it
Accurate risk prediction requires modeling irregular, heterogeneous clinical data over time, which current approaches often overlook.
- TRACE: Tracking Multimodal Clinical Trajectories for Inpatient Risk Predictionraises · addresses
Resistance to incidental information in clinical reasoning1 paper raises it · 0 address it
Models may misattribute or be distracted by irrelevant information in clinical documentation, leading to errors.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises
Learning from deployment experience without retraining1 paper raises it · 1 addresses it
Frozen models cannot adapt to new clinical evidence or updated guidelines without access to weights or additional training.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses

Named by an AI from these papers' abstracts.

Open problems

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Topics in this field

image segmentation · volumetric · medical image409 papers40 this week
radiology report generation · medical vision language · vision language models133 papers35 this week
clinical reasoning · question answering · language models210 papers21 this week
eeg foundation models · electroencephalography eeg · eeg foundation158 papers19 this week
patient history · clinical data · health records112 papers19 this week
electrocardiogram ecg · electrocardiogram · ecgs147 papers13 this week

Topics in this field

Active contributors · 90 days

Active contributors

Activity · 12 weeks

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arXiv cs.CVSep 24
Detecting Glaucoma Across Multi-ethnic Myopic and Non-Myopic Populations Using an Uncertainty-Aware Vision Transformer: A Multicentre Model Development and Validation Study
Raghavan Lavanya, Yangqin Feng, Ten Cheer Quek, Quan V. Hoang, Linda Yi-Chieh Poon +34
Background: Artificial intelligence (AI)-based glaucoma detection from colour fundus photographs (CFP) offers scalable screening, but performance may decline on external datasets because of differences in ground-truth definitions, populations, and coexisting conditions such as high myopia (HM). We developed and validated a Vision Transformer-based deep learning (DL) model for glaucoma detection across multi-ethnic cohorts with and without HM. Methods: A ViT-B/16 model with predictive uncertainty estimation was developed using 56,483 CFPs (57.1% with myopia; 14.4% with HM). Glaucoma labels were standardised using clinical, imaging, and perimetry data. The model was validated on 16 independent datasets across three continents, including four datasets with explicit HM labels. Findings: Internal AUROC was 98.7% (95% CI 98.2-99.1%), with sensitivity 94.5% and specificity 97.3%. Across 16 external datasets from eight countries, AUROCs ranged from 86.4% to 99.6%. In HM eyes, internal AUROC was 97.8% (95% CI 96.1-99.2%), with sensitivity 94.8% and specificity 93.7%. External HM AUROCs were 86.5% in the Beijing Eye Study and 93.3%, 91.8%, and 85.5% in hospital-based datasets from Taiwan,…
PDF arXiv
arXiv cs.AISep 24
Wearable ECG Quality Assessment: A Deep Learning and Ambulatory Context-Awareness Approach
Xiaopeng Mao, Marike Weisbjerg, Sadasivan Puthusserypady
This paper presents and evaluates a Deep Learning-based (DL-based) Signal Quality Assessment (SQA) model to distinguish between clean and noisy ambulatory Electrocardiograms (ECG). The model is trained on Copenhagen Center for Health Technology-Contextualized Arrhythmia Database (CACHET-CADB), which, to the best of our knowledge, is the first ambulatory ECG database with both physical and patient-reported contextual data. The model shows stable performance on different databases such as MIT-databases and the latest PyhsioNet/Cinc Challenge 2021 databases. Subsequently, the paper demonstrates how complicated ECG noise can be investigated by the SQA model and the physical contextual data.
PDF arXiv
arXiv cs.CVSep 24
When Misalignment Becomes Supervision: Structured Label Noise in Supervised Synthetic CT Generation
Valentin Boussot, Cedric Hemon, Caroline Lafond, Jean-Claude Nunes, Jean-Louis Dillenseger
Supervised synthetic CT (sCT) generation is commonly trained and evaluated as voxel-wise regression against registered reference CT images. In practice, MRI-CT and CBCT-CT pairs are aligned through registration procedures that leave residual misalignments. These residuals are not independent intensity noise but spatially coherent geometric discrepancies that act as structured label noise. We investigate how this registration-induced bias affects supervised MRI-to-CT and CBCT-to-CT synthesis on 1,784 paired patients covering five anatomical regions. Voxel-wise scores strongly depend on the consistency between the registration used to build the training targets and the one used for evaluation: models score best when both conventions match, showing that networks partly learn the geometric convention of the registration pipeline and that standard metrics reward it. Training on more anatomically consistent registrations reduces prediction variability and improves out-of-distribution robustness, and CT-only controls show that registration alone produces metric errors in the range of top challenge submissions. To mitigate the limits of voxel-wise supervision, we introduce a perceptual…
PDF arXiv
arXiv cs.CVSep 24
Segment-Level Risk Discovery in Online Handwriting for Alzheimer's Disease Detection
Changqing Gong, Huafeng Qin, Mounîm A. El-Yacoubi
Online handwriting provides a non-invasive and low-cost behavioral biomarker for Alzheimer's disease (AD) detection, as it reflects both cognitive planning and fine motor control. Existing handwriting-based AD detection methods usually rely on global trajectory features or whole-sample representations, which can be strongly affected by individual writing style, task-specific variation, and acquisition noise. In this paper, we propose NormPaST-Risk, a healthy-normative Paper-Air selective trajectory state-space risk network for interpretable AD detection from online handwriting. Instead of treating the entire trajectory as a single holistic representation, our method reformulates AD handwriting detection as local disease-relevant segment discovery. Specifically, a multi-scale temporal encoder captures stroke dynamics at different temporal resolutions, while a selective Paper-Air state-space encoder models long-range handwriting progression and distinguishes on-paper motor execution from in-air planning and transition behaviors. To explicitly characterize abnormal deviations, a healthy normative branch learns normal handwriting dynamics from healthy controls, and a task-aware…
PDF arXiv
arXiv cs.AISep 24
An auditable conditional-strategy framework for open-ended decision-making in complex lung cancer
Daoyun Wang, Zhicheng Huang, Huaiyuan Sun, Jiaqi Xu, Xiaowei Xu +37
Complex lung cancer decisions can involve several defensible pathways whose eligibility, sequencing and safety depend on unresolved information. Effective support must make explicit how patient conditions govern pathway eligibility, deferral and redirection. MedGPT Clinical Explorer (MCE) organizes alternatives, decision-changing unknowns, safety constraints and fallback into a conditional strategy for clinician review. To evaluate this representation in physician-authored strategies, multidisciplinary experts established case-specific references for 40 cases within a purposive 100-case corpus, and 250 physicians from 98 institutions produced 2,250 strategies under unaided, retrieval-reference and MCE-assisted conditions. MCE-assisted strategies expressed more applicable clinical requirements, measured by the Admissible Pathway Attainment Score (APAS; 0-100), than unaided strategies (adjusted difference, 12.87; 95% CI, 11.18-14.55) and retrieval-reference strategies (5.22; 3.52-6.93). With the same knowledge base available in the retrieval-reference and MCE-assisted conditions, the additional content centered on candidate pathways, decision-critical information and safety…
PDF arXiv
arXiv cs.CVSep 24
A Hybrid CNN--State-Space--Attention Backbone with Joint-Embedding Predictive Pretraining for 12-Lead ECG Classification
Yakoub Bazi, Sarah Aljuhani, Mohamad M. Al Rahhal, Mansour Zuair, Naif Alajlan
Automatic 12-lead electrocardiogram (ECG) classification requires representations that jointly capture local waveform morphology, long-range temporal dynamics, and cross-lead dependencies, yet integrating these properties within a single efficient architecture remains challenging. This paper introduces a hybrid CNN-SSM-Attention backbone for 12-lead ECG classification. A convolutional stem performs early waveform tokenization and temporal reduction, mixed state-space and depthwise-convolutional blocks model temporal dynamics and local morphology, and a late self-attention stage enables global token interaction at reduced resolution. To improve transfer from unlabeled data, we further develop an ECG-oriented Joint-Embedding Predictive Pretraining (JEPA) framework. Unlike ViT-based JEPA methods that mask patch tokens before the encoder, the proposed method samples span masks at the latent temporal resolution and projects them back to the waveform domain, then predicts clean latent targets from a momentum encoder without waveform reconstruction. Experiments on CPSC2018, Chapman-Shaoxing, and PTB-XL, with pretraining on approximately 350K unlabeled CODE-15 recordings, show that the…
PDF arXiv

Papers

Topics in this field

image segmentation · volumetric · medical image409 papers40 this week
radiology report generation · medical vision language · vision language models133 papers35 this week
clinical reasoning · question answering · language models210 papers21 this week
eeg foundation models · electroencephalography eeg · eeg foundation158 papers19 this week
patient history · clinical data · health records112 papers19 this week
electrocardiogram ecg · electrocardiogram · ecgs147 papers13 this week

Active contributors · 90 days

Activity · 12 weeks

Recent papers

All papers in Research

arXiv cs.CVSep 24
Detecting Glaucoma Across Multi-ethnic Myopic and Non-Myopic Populations Using an Uncertainty-Aware Vision Transformer: A Multicentre Model Development and Validation Study
Raghavan Lavanya, Yangqin Feng, Ten Cheer Quek, Quan V. Hoang, Linda Yi-Chieh Poon +34
Background: Artificial intelligence (AI)-based glaucoma detection from colour fundus photographs (CFP) offers scalable screening, but performance may decline on external datasets because of differences in ground-truth definitions, populations, and coexisting conditions such as high myopia (HM). We developed and validated a Vision Transformer-based deep learning (DL) model for glaucoma detection across multi-ethnic cohorts with and without HM. Methods: A ViT-B/16 model with predictive uncertainty estimation was developed using 56,483 CFPs (57.1% with myopia; 14.4% with HM). Glaucoma labels were standardised using clinical, imaging, and perimetry data. The model was validated on 16 independent datasets across three continents, including four datasets with explicit HM labels. Findings: Internal AUROC was 98.7% (95% CI 98.2-99.1%), with sensitivity 94.5% and specificity 97.3%. Across 16 external datasets from eight countries, AUROCs ranged from 86.4% to 99.6%. In HM eyes, internal AUROC was 97.8% (95% CI 96.1-99.2%), with sensitivity 94.8% and specificity 93.7%. External HM AUROCs were 86.5% in the Beijing Eye Study and 93.3%, 91.8%, and 85.5% in hospital-based datasets from Taiwan,…
PDF arXiv
arXiv cs.AISep 24
Wearable ECG Quality Assessment: A Deep Learning and Ambulatory Context-Awareness Approach
Xiaopeng Mao, Marike Weisbjerg, Sadasivan Puthusserypady
This paper presents and evaluates a Deep Learning-based (DL-based) Signal Quality Assessment (SQA) model to distinguish between clean and noisy ambulatory Electrocardiograms (ECG). The model is trained on Copenhagen Center for Health Technology-Contextualized Arrhythmia Database (CACHET-CADB), which, to the best of our knowledge, is the first ambulatory ECG database with both physical and patient-reported contextual data. The model shows stable performance on different databases such as MIT-databases and the latest PyhsioNet/Cinc Challenge 2021 databases. Subsequently, the paper demonstrates how complicated ECG noise can be investigated by the SQA model and the physical contextual data.
PDF arXiv
arXiv cs.CVSep 24
When Misalignment Becomes Supervision: Structured Label Noise in Supervised Synthetic CT Generation
Valentin Boussot, Cedric Hemon, Caroline Lafond, Jean-Claude Nunes, Jean-Louis Dillenseger
Supervised synthetic CT (sCT) generation is commonly trained and evaluated as voxel-wise regression against registered reference CT images. In practice, MRI-CT and CBCT-CT pairs are aligned through registration procedures that leave residual misalignments. These residuals are not independent intensity noise but spatially coherent geometric discrepancies that act as structured label noise. We investigate how this registration-induced bias affects supervised MRI-to-CT and CBCT-to-CT synthesis on 1,784 paired patients covering five anatomical regions. Voxel-wise scores strongly depend on the consistency between the registration used to build the training targets and the one used for evaluation: models score best when both conventions match, showing that networks partly learn the geometric convention of the registration pipeline and that standard metrics reward it. Training on more anatomically consistent registrations reduces prediction variability and improves out-of-distribution robustness, and CT-only controls show that registration alone produces metric errors in the range of top challenge submissions. To mitigate the limits of voxel-wise supervision, we introduce a perceptual…
PDF arXiv
arXiv cs.CVSep 24
Segment-Level Risk Discovery in Online Handwriting for Alzheimer's Disease Detection
Changqing Gong, Huafeng Qin, Mounîm A. El-Yacoubi
Online handwriting provides a non-invasive and low-cost behavioral biomarker for Alzheimer's disease (AD) detection, as it reflects both cognitive planning and fine motor control. Existing handwriting-based AD detection methods usually rely on global trajectory features or whole-sample representations, which can be strongly affected by individual writing style, task-specific variation, and acquisition noise. In this paper, we propose NormPaST-Risk, a healthy-normative Paper-Air selective trajectory state-space risk network for interpretable AD detection from online handwriting. Instead of treating the entire trajectory as a single holistic representation, our method reformulates AD handwriting detection as local disease-relevant segment discovery. Specifically, a multi-scale temporal encoder captures stroke dynamics at different temporal resolutions, while a selective Paper-Air state-space encoder models long-range handwriting progression and distinguishes on-paper motor execution from in-air planning and transition behaviors. To explicitly characterize abnormal deviations, a healthy normative branch learns normal handwriting dynamics from healthy controls, and a task-aware…
PDF arXiv
arXiv cs.AISep 24
An auditable conditional-strategy framework for open-ended decision-making in complex lung cancer
Daoyun Wang, Zhicheng Huang, Huaiyuan Sun, Jiaqi Xu, Xiaowei Xu +37
Complex lung cancer decisions can involve several defensible pathways whose eligibility, sequencing and safety depend on unresolved information. Effective support must make explicit how patient conditions govern pathway eligibility, deferral and redirection. MedGPT Clinical Explorer (MCE) organizes alternatives, decision-changing unknowns, safety constraints and fallback into a conditional strategy for clinician review. To evaluate this representation in physician-authored strategies, multidisciplinary experts established case-specific references for 40 cases within a purposive 100-case corpus, and 250 physicians from 98 institutions produced 2,250 strategies under unaided, retrieval-reference and MCE-assisted conditions. MCE-assisted strategies expressed more applicable clinical requirements, measured by the Admissible Pathway Attainment Score (APAS; 0-100), than unaided strategies (adjusted difference, 12.87; 95% CI, 11.18-14.55) and retrieval-reference strategies (5.22; 3.52-6.93). With the same knowledge base available in the retrieval-reference and MCE-assisted conditions, the additional content centered on candidate pathways, decision-critical information and safety…
PDF arXiv
arXiv cs.CVSep 24
A Hybrid CNN--State-Space--Attention Backbone with Joint-Embedding Predictive Pretraining for 12-Lead ECG Classification
Yakoub Bazi, Sarah Aljuhani, Mohamad M. Al Rahhal, Mansour Zuair, Naif Alajlan
Automatic 12-lead electrocardiogram (ECG) classification requires representations that jointly capture local waveform morphology, long-range temporal dynamics, and cross-lead dependencies, yet integrating these properties within a single efficient architecture remains challenging. This paper introduces a hybrid CNN-SSM-Attention backbone for 12-lead ECG classification. A convolutional stem performs early waveform tokenization and temporal reduction, mixed state-space and depthwise-convolutional blocks model temporal dynamics and local morphology, and a late self-attention stage enables global token interaction at reduced resolution. To improve transfer from unlabeled data, we further develop an ECG-oriented Joint-Embedding Predictive Pretraining (JEPA) framework. Unlike ViT-based JEPA methods that mask patch tokens before the encoder, the proposed method samples span masks at the latent temporal resolution and projects them back to the waveform domain, then predicts clean latent targets from a momentum encoder without waveform reconstruction. Experiments on CPSC2018, Chapman-Shaoxing, and PTB-XL, with pretraining on approximately 350K unlabeled CODE-15 recordings, show that the…
PDF arXiv

Open problems in Image segmentation

Lack of benchmarks for real-world clinical deployment1 paper raises it · 0 address it
Current benchmarks do not reflect how clinicians actually use AI systems, limiting their predictive value for real-world performance.
- Clinician use of language models diverges from how the models are evaluatedraises
Handling gigapixel whole-slide images in segmentation1 paper raises it · 1 addresses it
Existing models operate at patch scale, but clinical supervision and labels are at the whole-slide level, creating a mismatch.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Temporal modeling of multimodal clinical trajectories1 paper raises it · 1 addresses it
Accurate risk prediction requires modeling irregular, heterogeneous clinical data over time, which current approaches often overlook.
- TRACE: Tracking Multimodal Clinical Trajectories for Inpatient Risk Predictionraises · addresses
Resistance to incidental information in clinical reasoning1 paper raises it · 0 address it
Models may misattribute or be distracted by irrelevant information in clinical documentation, leading to errors.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises
Learning from deployment experience without retraining1 paper raises it · 1 addresses it
Frozen models cannot adapt to new clinical evidence or updated guidelines without access to weights or additional training.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses

Named by an AI from these papers' abstracts.

Fields · AI · updated 7m ago

Image segmentation

Found by the topic model: image segmentation, clinical reasoning, eeg foundation models.

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