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Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.

Open problems

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Topics in this field

image segmentation · volumetric · medical image403 papers50 this week
radiology report generation · medical vision language · vision language models127 papers33 this week
clinical reasoning · question answering · language models205 papers24 this week
patient history · clinical data · health records109 papers22 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers21 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Topics in this field

Active contributors · 90 days

Active contributors

Activity · 12 weeks

Activity

Recent papers

All papers in Research

arXiv cs.SDSep 28
SincDPNet: Interpretable Raw-Waveform Bathroom Activity Recognition for Assistive Living
Debolina Chowdhury, Suman Samui, Sujoy Saha
Bathroom acoustic-event recognition can support ambient assisted living in settings where continuous video monitoring is undesirable. However, practical deployment requires models that are compact, interpretable, and robust to changes in the recording environment. This work introduces \dataset{}, a seven-class bathroom acoustic-event dataset containing 21{,}387 annotated clips recorded across five environments, and proposes SincDPNet, a compact raw-waveform classifier with a learnable sinc filter bank followed by a depthwise-separable convolutional body. Each sinc filter is controlled by two frequency parameters, allowing the learned passbands to be inspected directly in hertz while keeping the front end small. To reduce room-specific leakage, recording sessions and environments are separated before overlapping windows are assigned to the training, validation, and test partitions. We further use multi-objective Bayesian optimization as a design tool to examine the validation performance--model-size trade-off across 24 configurations. The selected designs span different operating points: the best-performing model achieves 80.2\% accuracy and 0.760 macro-F1 with 14{,}040…
PDF arXiv
arXiv cs.CVSep 28
Role-Guided MOE for Encoder-Level Pathology Representation Learning in WSI Classification
Xinyu Ma, Xing Yang, Hongtao Jin, Guoquan Zhang, Shijie Zhang +2
Whole slide image classification is a fundamental task in computational pathology, where patch representation quality directly affects downstream aggregation and slide-level discriminability. Pathology foundation models are widely adopted as frozen feature extractors for WSI classification; however, their fixed encoders may produce representations insufficiently adapted to target-specific tissue patterns and discriminative cues. Fine-tuning can improve target adaptation, but introduces a trade-off between pathology-specific representation capacity and adaptation efficiency, particularly in data-scarce settings. To address this, we propose a pathology role-guided mixture-of-experts feed-forward network (MoE-FFN) framework for efficient encoder-level representation learning. We design a two-stage training paradigm to establish and adapt pathology-aware expert specialization. In source-domain expert initialization, pathology-specific priors are distilled from a frozen Virchow2 teacher into a lightweight DINOv2-small student, while role prototypes serve as weak pathological anchors to encourage distinct expert functions. MoE-FFN blocks are introduced into selected high-level…
PDF arXiv
arXiv cs.LGSep 28
Separating personal from population gains when calibrating EEG foundation models for new users
Xilin Tao, Kani Chen
Foundation models are increasingly adapted to individual users, but an apparent personalization gain can simply reflect a stronger population model. This distinction matters for brain-computer interfaces, where every new user must be calibrated. We evaluated personal adaptation of three frozen EEG foundation models (CBraMod, REVE and LaBraM) in 235 held-out subjects from three motor-imagery datasets, comparing each subject's adapter with the population model and with adapters fitted to other subjects. Using all first-half session labels, personal adapters improved mean balanced accuracy over the population model by 1.5-5.4 percentage points and outperformed exchanged adapters by 2.3-7.3 points in all nine model-dataset combinations. The size of this benefit depended on population training: with four times the original budget, median gains remained positive (1.0-2.0 points) but were smaller for every model, and no population model reached a confirmed plateau. Acquiring the benefit cheaply was unreliable: few-label calibration was consistently non-negative on only one dataset, and in CBraMod neither unlabeled context nor meta-learned initialization outperformed matched controls.…
PDF arXiv
arXiv cs.AISep 28
Applying Language Models in Clinical Medicine: Recent Trends and Perspectives
Erik Aerts
The use and applicability of artificial intelligence (AI) in medical research and clinical practice has received increasing attention in the literature over recent years. The emergence of large language models (LLMs) has expanded discussions in regards to applications of AI within healthcare. While traditional deep learning based AI applications in medicine have often focused on specific and defined tasks, LLMs offer broader capabilities and flexibility in working with available data,. At the same time of writing, the integration of LLMs into medical settings raises important questions regarding their reliability, accuracy, transparency, safety, and appropriate role in a medical setting. This text presents and discusses recent talks and articles concerning the application of LLMs in medicine, with particular emphasis on their potential utility in research and clinical practice. It considers both the opportunities offered by these technologies and the challenges associated with their implementation, aiming to provide a perspective on the current and emerging role of LLMs within the medical field.
PDF arXiv
arXiv cs.CVSep 28
From Pixel Generation to Topological Inference: Structural Dual Super-Resolution for Trustworthy Cross-Physical-Domain Trabecular Morphology Learning
Fan Zhang, Yi Zhang, Ling Wang
Clinical CT and UHRCT cannot resolve individual trabeculae, whereas synchrotron radiation microCT (SRuCT) provides high-resolution references but is not applicable for in vivo imaging. The two domains differ by a 32x resolution gap, are only coarsely paired, and exhibit severe physical differences including partial volume effects, noise, and artifacts. Existing super-resolution networks and pretrained-prior methods (GLEAN/StyleGAN2, Stable SR/LDM) underperform because they target pixel generation---diverse details and SSIM/PSNR---and do not model these physical differences. Pixel generation for a 32x resolution gap is intrinsically ill-posed. We propose a paradigm shift from pixel generation to topological inference: deterministically predicting invariant microstructures from macro-scale low-resolution inputs, evaluated by morphological parameters. The core of our 2D morphology learning lies in training on 2D slices while evaluating on 3D morphological parameters, ensuring that the learned representations capture true three-dimensional trabecular topology rather than 2D pixel statistics. We realize this paradigm via structural dual super-resolution, coupling forward physical…
PDF arXiv
arXiv cs.CVSep 28
Revitalizing Medical Time Series with Vision-Informed Retrieval: A Vision-Language Perspective
Guoqi Yu, Juncheng Wang, Shujun Wang
Medical time series (MedTS) underpin many clinical classification tasks, yet existing methods usually represent them only as numerical sequences and underuse the morphology that is explicit in waveform inspection. To bridge this gap, we introduce Vision-Informed Retrieval (ViRe), which uses a frozen VLM-derived waveform representation as a morphology-aware Query to guide retrieval from raw numerical MedTS features. Specifically, a Vision Query is extracted using pre-trained vision-language models (VLMs) to obtain morphology-aware priors from waveform plots. A tailored attention-based cross-modal retrieval mechanism then uses the Vision Query to select morphology-relevant temporal and channel evidence from the numerical representation. ViRe demonstrates strong effectiveness against ten established baselines, yielding an overall 6.42% relative improvement over the previous state of the art across six public benchmarks. Code, training scripts, and reproducibility materials are publicly available in the GitHub Repository: https://github.com/Levi-Ackman/ViRe.
PDF arXiv

Papers

Topics in this field

image segmentation · volumetric · medical image403 papers50 this week
radiology report generation · medical vision language · vision language models127 papers33 this week
clinical reasoning · question answering · language models205 papers24 this week
patient history · clinical data · health records109 papers22 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers21 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Active contributors · 90 days

Recent papers

All papers in Research

arXiv cs.SDSep 28
SincDPNet: Interpretable Raw-Waveform Bathroom Activity Recognition for Assistive Living
Debolina Chowdhury, Suman Samui, Sujoy Saha
Bathroom acoustic-event recognition can support ambient assisted living in settings where continuous video monitoring is undesirable. However, practical deployment requires models that are compact, interpretable, and robust to changes in the recording environment. This work introduces \dataset{}, a seven-class bathroom acoustic-event dataset containing 21{,}387 annotated clips recorded across five environments, and proposes SincDPNet, a compact raw-waveform classifier with a learnable sinc filter bank followed by a depthwise-separable convolutional body. Each sinc filter is controlled by two frequency parameters, allowing the learned passbands to be inspected directly in hertz while keeping the front end small. To reduce room-specific leakage, recording sessions and environments are separated before overlapping windows are assigned to the training, validation, and test partitions. We further use multi-objective Bayesian optimization as a design tool to examine the validation performance--model-size trade-off across 24 configurations. The selected designs span different operating points: the best-performing model achieves 80.2\% accuracy and 0.760 macro-F1 with 14{,}040…
PDF arXiv
arXiv cs.CVSep 28
Role-Guided MOE for Encoder-Level Pathology Representation Learning in WSI Classification
Xinyu Ma, Xing Yang, Hongtao Jin, Guoquan Zhang, Shijie Zhang +2
Whole slide image classification is a fundamental task in computational pathology, where patch representation quality directly affects downstream aggregation and slide-level discriminability. Pathology foundation models are widely adopted as frozen feature extractors for WSI classification; however, their fixed encoders may produce representations insufficiently adapted to target-specific tissue patterns and discriminative cues. Fine-tuning can improve target adaptation, but introduces a trade-off between pathology-specific representation capacity and adaptation efficiency, particularly in data-scarce settings. To address this, we propose a pathology role-guided mixture-of-experts feed-forward network (MoE-FFN) framework for efficient encoder-level representation learning. We design a two-stage training paradigm to establish and adapt pathology-aware expert specialization. In source-domain expert initialization, pathology-specific priors are distilled from a frozen Virchow2 teacher into a lightweight DINOv2-small student, while role prototypes serve as weak pathological anchors to encourage distinct expert functions. MoE-FFN blocks are introduced into selected high-level…
PDF arXiv
arXiv cs.LGSep 28
Separating personal from population gains when calibrating EEG foundation models for new users
Xilin Tao, Kani Chen
Foundation models are increasingly adapted to individual users, but an apparent personalization gain can simply reflect a stronger population model. This distinction matters for brain-computer interfaces, where every new user must be calibrated. We evaluated personal adaptation of three frozen EEG foundation models (CBraMod, REVE and LaBraM) in 235 held-out subjects from three motor-imagery datasets, comparing each subject's adapter with the population model and with adapters fitted to other subjects. Using all first-half session labels, personal adapters improved mean balanced accuracy over the population model by 1.5-5.4 percentage points and outperformed exchanged adapters by 2.3-7.3 points in all nine model-dataset combinations. The size of this benefit depended on population training: with four times the original budget, median gains remained positive (1.0-2.0 points) but were smaller for every model, and no population model reached a confirmed plateau. Acquiring the benefit cheaply was unreliable: few-label calibration was consistently non-negative on only one dataset, and in CBraMod neither unlabeled context nor meta-learned initialization outperformed matched controls.…
PDF arXiv
arXiv cs.AISep 28
Applying Language Models in Clinical Medicine: Recent Trends and Perspectives
Erik Aerts
The use and applicability of artificial intelligence (AI) in medical research and clinical practice has received increasing attention in the literature over recent years. The emergence of large language models (LLMs) has expanded discussions in regards to applications of AI within healthcare. While traditional deep learning based AI applications in medicine have often focused on specific and defined tasks, LLMs offer broader capabilities and flexibility in working with available data,. At the same time of writing, the integration of LLMs into medical settings raises important questions regarding their reliability, accuracy, transparency, safety, and appropriate role in a medical setting. This text presents and discusses recent talks and articles concerning the application of LLMs in medicine, with particular emphasis on their potential utility in research and clinical practice. It considers both the opportunities offered by these technologies and the challenges associated with their implementation, aiming to provide a perspective on the current and emerging role of LLMs within the medical field.
PDF arXiv
arXiv cs.CVSep 28
From Pixel Generation to Topological Inference: Structural Dual Super-Resolution for Trustworthy Cross-Physical-Domain Trabecular Morphology Learning
Fan Zhang, Yi Zhang, Ling Wang
Clinical CT and UHRCT cannot resolve individual trabeculae, whereas synchrotron radiation microCT (SRuCT) provides high-resolution references but is not applicable for in vivo imaging. The two domains differ by a 32x resolution gap, are only coarsely paired, and exhibit severe physical differences including partial volume effects, noise, and artifacts. Existing super-resolution networks and pretrained-prior methods (GLEAN/StyleGAN2, Stable SR/LDM) underperform because they target pixel generation---diverse details and SSIM/PSNR---and do not model these physical differences. Pixel generation for a 32x resolution gap is intrinsically ill-posed. We propose a paradigm shift from pixel generation to topological inference: deterministically predicting invariant microstructures from macro-scale low-resolution inputs, evaluated by morphological parameters. The core of our 2D morphology learning lies in training on 2D slices while evaluating on 3D morphological parameters, ensuring that the learned representations capture true three-dimensional trabecular topology rather than 2D pixel statistics. We realize this paradigm via structural dual super-resolution, coupling forward physical…
PDF arXiv
arXiv cs.CVSep 28
Revitalizing Medical Time Series with Vision-Informed Retrieval: A Vision-Language Perspective
Guoqi Yu, Juncheng Wang, Shujun Wang
Medical time series (MedTS) underpin many clinical classification tasks, yet existing methods usually represent them only as numerical sequences and underuse the morphology that is explicit in waveform inspection. To bridge this gap, we introduce Vision-Informed Retrieval (ViRe), which uses a frozen VLM-derived waveform representation as a morphology-aware Query to guide retrieval from raw numerical MedTS features. Specifically, a Vision Query is extracted using pre-trained vision-language models (VLMs) to obtain morphology-aware priors from waveform plots. A tailored attention-based cross-modal retrieval mechanism then uses the Vision Query to select morphology-relevant temporal and channel evidence from the numerical representation. ViRe demonstrates strong effectiveness against ten established baselines, yielding an overall 6.42% relative improvement over the previous state of the art across six public benchmarks. Code, training scripts, and reproducibility materials are publicly available in the GitHub Repository: https://github.com/Levi-Ackman/ViRe.
PDF arXiv

Activity · 12 weeks

Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.

Fields · AI · updated 5m ago

Image segmentation

Found by the topic model: image segmentation, clinical reasoning, eeg foundation models.

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