Papers

Field

Top tools here

Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.

Open problems

Recently funded

Topics in this field

image segmentation · volumetric · medical image403 papers48 this week
radiology report generation · medical vision language · vision language models127 papers33 this week
clinical reasoning · question answering · language models205 papers24 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers21 this week
patient history · clinical data · health records109 papers20 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Topics in this field

Active contributors · 90 days

Active contributors

Activity · 12 weeks

Activity

Recent papers

All papers in Research

arXiv cs.CLSep 28
Recursive LLM Degradation in Biomedical Question Answering: A Cross-Generation Study
Bibek Bhandari, Kshitij Lingthep
Repeatedly training language models on their own generated data may create a synthetic-data feedback loop in which errors and distributional biases are reintroduced into subsequent training datasets. This paper studies that process in biomedical question answering (QA) using PubMedQA and two Qwen2.5 model sizes, 0.5B and 3B parameters. The study compares a recursive synthetic-data condition, in which generation G(k+1) is trained on answers produced by G(k), against a Human-Control condition that repeatedly uses the original human training data. The study evaluates across four generations from G0-G3 with two random seeds (42 and 123) and a fixed evaluation set of 1,000 expert-labeled samples. The evaluation includes disease and chemical entity F1, context-supported rate, lexical and semantic similarity, answer length, repetition rate, and other evaluation metrics. The Recursive condition for both model sizes and both seeds showed larger declines than the Human-Control condition in disease entity F1, chemical entity F1, context-supported rate, ROUGE-L, and cosine similarity. Under the fixed no-repeat 3-gram decoding constraint, the main observed behavioral change was increased…
PDF arXiv
arXiv cs.CVSep 28
SegBanana: Steering Unified Multimodal Models into Medical Segmenters
Xiaoye Liang, Ye Yan, Mingze Yin, Shikun Feng, Mai Xu +3
Medical image segmentation remains challenging in practical deployment, as models often struggle to generalize beyond the distributions covered by their training data and high-quality pixel-level annotations are typically unavailable for adaptation. Inspired by the cross-task transferability of large language models, we investigate whether unified multimodal models (UMMs) can transfer their pretrained visual understanding, reasoning, and generation capabilities to medical image segmentation without task-specific post-training. By recasting segmentation as structured visual generation, we find that frontier UMMs (e.g., Nano Banana) already exhibit basic segmentation capabilities across diverse clinical scenarios, but still struggle with challenging tasks requiring specialized anatomical or domain-specific knowledge. We further show that these limitations can be effectively mitigated by incorporating visual anatomical knowledge from in-context exemplars, expanding candidate solutions through repeated sampling, and refining suboptimal predictions via targeted editing.Motivated by these observations, we propose SegBanana, to our knowledge, the first agentic visual generation…
PDF arXiv
arXiv stat.MLSep 28
Functional Autoencoders for Amplitude-Phase Representation Learning
Peida Wu, Xinyang Xiong, Pengcheng Zeng
Functional data are intrinsically infinite-dimensional, and often exhibit phase variation, where corresponding events occur at different times across observations. Existing linear dimension reduction methods struggle with nonlinear amplitude variation, while functional autoencoders without an explicit warp entangle temporal misalignment with shape. We propose the Amplitude--Phase Functional Autoencoders (AP-FAE), an unsupervised framework for functional data that spans both univariate and multivariate cases, with emphasis on the multivariate setting, and factorizes the latent space into separate amplitude and phase embeddings derived from all channels. A smooth functional decoder reconstructs channel-specific amplitude functions in canonical time, and a shared monotone, endpoint-preserving warp captures phase variation. We prove a bound linking amplitude recovery to registration, reconstruction, and noise errors, and validate it numerically. Across synthetic data and six real-world benchmarks, AP-FAE outperforms state-of-the-art baselines on most clustering and alignment metrics and on all reconstruction metrics. Clustering with amplitude embeddings alone consistently surpasses…
PDF arXiv
arXiv cs.CVSep 28
Natural Image Autoencoder-Based fMRI Representations for Trait and State Prediction
Juhyeon Park, Yeonwoo Kim, Peter Yongho Kim, Yansen Wang, Mingqing Xiao +3
Foundation models pre-trained on large-scale fMRI datasets have shown strong downstream performance, but at substantial data and computation cost. To investigate how much fMRI-specific pre-training is actually needed for such performance, we introduce FReD, which derives fMRI representations from a frozen Deep Compression AutoEncoder (DCAE) pre-trained exclusively on natural images and pairs them with a task specific readout. For trait prediction, FReD summarizes frame-wise representations by their temporal mean and log-standard deviation and applies linear probing, with late fusion across two normalization schemes. For state prediction, it represents each frame as a single token and models temporal dependencies with a shallow Transformer. Across four resting-state datasets spanning six trait-prediction targets, linear probes on frozen DCAE features generally outperform those on fMRI foundation model representations and remain competitive with fully fine-tuned fMRI foundation models. On three task-fMRI state-prediction tasks, a temporal readout on DCAE features performs comparably to the strongest foundation models evaluated. A Gaussian injection analysis further shows that…
PDF arXiv
arXiv cs.LGSep 28
ExpertoRhythm: Morphology-Aware Learning for Waveform Reconstruction and Cuffless Blood Pressure Estimation from Single-Channel PPG
Amir Arjomand, Kenneth B. Kent, Georgiy Krylov
Continuous cuffless blood pressure (BP) monitoring from photoplethysmography (PPG) has strong potential for wearable health and telemonitoring, but accurate estimation remains difficult because PPG-to-BP mapping must preserve subtle waveform morphology and pressure-range-dependent dynamics. We introduce ExpertoRhythm, an attention-enhanced 1D U-Net that reconstructs the arterial blood pressure (ABP) waveform from a single-channel PPG signal and derives systolic and diastolic BP directly from the reconstructed waveform. The central contribution is a composite morphology-aware learning objective that integrates range-weighted SmoothL1 reconstruction with a window-range regularizer to emphasize high-dynamic BP segments and reduce amplitude under/over-shoot. On the UCI cuff-less BP dataset with 942 subjects, ExpertoRhythm achieves 2.46/1.46 mmHg MAE for systolic/diastolic BP (SBP/DBP), while obtaining a 30.4% average relative error reduction over pure MSE across waveform reconstruction and BP estimation metrics. Clinical-style evaluation further demonstrates low bias and strong agreement across the BP range, including high-pressure windows up to 200 mmHg, satisfying AAMI criteria and…
PDF arXiv
arXiv cs.CLSep 28
Understanding Clinical Cognitive Dialogues Using Large Language Models
Vishalakshi Arumugam, Dan Schumacher, Veronica Rammouz, Erfan Nourbakhsh, Enrique Gonzalez Guerrero +2
In-person cognitive assessment is both a test and an interaction. Clinicians explain tasks, repair misunderstandings, and adapt to patient responses, while patients may hesitate, seek clarification, or disengage. Yet clinical dialogue resources rarely label the interaction structure needed to study these behaviors at scale. We present an de-identified corpus of 33 cognitive assessment conversations with 8,250 utterances annotated for three speaker roles and 56 dialogue acts. We use this corpus to benchmark large language models on fine-grained dialogue-act classification and next-patient-utterance generation. We also test whether out-of-domain instruction data and explanation-augmented training transfer to this clinical setting. Instruction tuning produces the strongest patient-utterance reference matching and improves classification accuracy. Reasoning-aware fine-tuning produces the strongest classification results among the LLaMA-3.1-8B variants. However, even the best models struggle to separate closely related dialogue acts, showing that broad conversational intent is easier to recognize than fine-grained communicative function. The corpus and benchmark make interaction…
PDF arXiv

Papers

Topics in this field

image segmentation · volumetric · medical image403 papers48 this week
radiology report generation · medical vision language · vision language models127 papers33 this week
clinical reasoning · question answering · language models205 papers24 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers21 this week
patient history · clinical data · health records109 papers20 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Active contributors · 90 days

Recent papers

All papers in Research

arXiv cs.CLSep 28
Recursive LLM Degradation in Biomedical Question Answering: A Cross-Generation Study
Bibek Bhandari, Kshitij Lingthep
Repeatedly training language models on their own generated data may create a synthetic-data feedback loop in which errors and distributional biases are reintroduced into subsequent training datasets. This paper studies that process in biomedical question answering (QA) using PubMedQA and two Qwen2.5 model sizes, 0.5B and 3B parameters. The study compares a recursive synthetic-data condition, in which generation G(k+1) is trained on answers produced by G(k), against a Human-Control condition that repeatedly uses the original human training data. The study evaluates across four generations from G0-G3 with two random seeds (42 and 123) and a fixed evaluation set of 1,000 expert-labeled samples. The evaluation includes disease and chemical entity F1, context-supported rate, lexical and semantic similarity, answer length, repetition rate, and other evaluation metrics. The Recursive condition for both model sizes and both seeds showed larger declines than the Human-Control condition in disease entity F1, chemical entity F1, context-supported rate, ROUGE-L, and cosine similarity. Under the fixed no-repeat 3-gram decoding constraint, the main observed behavioral change was increased…
PDF arXiv
arXiv cs.CVSep 28
SegBanana: Steering Unified Multimodal Models into Medical Segmenters
Xiaoye Liang, Ye Yan, Mingze Yin, Shikun Feng, Mai Xu +3
Medical image segmentation remains challenging in practical deployment, as models often struggle to generalize beyond the distributions covered by their training data and high-quality pixel-level annotations are typically unavailable for adaptation. Inspired by the cross-task transferability of large language models, we investigate whether unified multimodal models (UMMs) can transfer their pretrained visual understanding, reasoning, and generation capabilities to medical image segmentation without task-specific post-training. By recasting segmentation as structured visual generation, we find that frontier UMMs (e.g., Nano Banana) already exhibit basic segmentation capabilities across diverse clinical scenarios, but still struggle with challenging tasks requiring specialized anatomical or domain-specific knowledge. We further show that these limitations can be effectively mitigated by incorporating visual anatomical knowledge from in-context exemplars, expanding candidate solutions through repeated sampling, and refining suboptimal predictions via targeted editing.Motivated by these observations, we propose SegBanana, to our knowledge, the first agentic visual generation…
PDF arXiv
arXiv stat.MLSep 28
Functional Autoencoders for Amplitude-Phase Representation Learning
Peida Wu, Xinyang Xiong, Pengcheng Zeng
Functional data are intrinsically infinite-dimensional, and often exhibit phase variation, where corresponding events occur at different times across observations. Existing linear dimension reduction methods struggle with nonlinear amplitude variation, while functional autoencoders without an explicit warp entangle temporal misalignment with shape. We propose the Amplitude--Phase Functional Autoencoders (AP-FAE), an unsupervised framework for functional data that spans both univariate and multivariate cases, with emphasis on the multivariate setting, and factorizes the latent space into separate amplitude and phase embeddings derived from all channels. A smooth functional decoder reconstructs channel-specific amplitude functions in canonical time, and a shared monotone, endpoint-preserving warp captures phase variation. We prove a bound linking amplitude recovery to registration, reconstruction, and noise errors, and validate it numerically. Across synthetic data and six real-world benchmarks, AP-FAE outperforms state-of-the-art baselines on most clustering and alignment metrics and on all reconstruction metrics. Clustering with amplitude embeddings alone consistently surpasses…
PDF arXiv
arXiv cs.CVSep 28
Natural Image Autoencoder-Based fMRI Representations for Trait and State Prediction
Juhyeon Park, Yeonwoo Kim, Peter Yongho Kim, Yansen Wang, Mingqing Xiao +3
Foundation models pre-trained on large-scale fMRI datasets have shown strong downstream performance, but at substantial data and computation cost. To investigate how much fMRI-specific pre-training is actually needed for such performance, we introduce FReD, which derives fMRI representations from a frozen Deep Compression AutoEncoder (DCAE) pre-trained exclusively on natural images and pairs them with a task specific readout. For trait prediction, FReD summarizes frame-wise representations by their temporal mean and log-standard deviation and applies linear probing, with late fusion across two normalization schemes. For state prediction, it represents each frame as a single token and models temporal dependencies with a shallow Transformer. Across four resting-state datasets spanning six trait-prediction targets, linear probes on frozen DCAE features generally outperform those on fMRI foundation model representations and remain competitive with fully fine-tuned fMRI foundation models. On three task-fMRI state-prediction tasks, a temporal readout on DCAE features performs comparably to the strongest foundation models evaluated. A Gaussian injection analysis further shows that…
PDF arXiv
arXiv cs.LGSep 28
ExpertoRhythm: Morphology-Aware Learning for Waveform Reconstruction and Cuffless Blood Pressure Estimation from Single-Channel PPG
Amir Arjomand, Kenneth B. Kent, Georgiy Krylov
Continuous cuffless blood pressure (BP) monitoring from photoplethysmography (PPG) has strong potential for wearable health and telemonitoring, but accurate estimation remains difficult because PPG-to-BP mapping must preserve subtle waveform morphology and pressure-range-dependent dynamics. We introduce ExpertoRhythm, an attention-enhanced 1D U-Net that reconstructs the arterial blood pressure (ABP) waveform from a single-channel PPG signal and derives systolic and diastolic BP directly from the reconstructed waveform. The central contribution is a composite morphology-aware learning objective that integrates range-weighted SmoothL1 reconstruction with a window-range regularizer to emphasize high-dynamic BP segments and reduce amplitude under/over-shoot. On the UCI cuff-less BP dataset with 942 subjects, ExpertoRhythm achieves 2.46/1.46 mmHg MAE for systolic/diastolic BP (SBP/DBP), while obtaining a 30.4% average relative error reduction over pure MSE across waveform reconstruction and BP estimation metrics. Clinical-style evaluation further demonstrates low bias and strong agreement across the BP range, including high-pressure windows up to 200 mmHg, satisfying AAMI criteria and…
PDF arXiv
arXiv cs.CLSep 28
Understanding Clinical Cognitive Dialogues Using Large Language Models
Vishalakshi Arumugam, Dan Schumacher, Veronica Rammouz, Erfan Nourbakhsh, Enrique Gonzalez Guerrero +2
In-person cognitive assessment is both a test and an interaction. Clinicians explain tasks, repair misunderstandings, and adapt to patient responses, while patients may hesitate, seek clarification, or disengage. Yet clinical dialogue resources rarely label the interaction structure needed to study these behaviors at scale. We present an de-identified corpus of 33 cognitive assessment conversations with 8,250 utterances annotated for three speaker roles and 56 dialogue acts. We use this corpus to benchmark large language models on fine-grained dialogue-act classification and next-patient-utterance generation. We also test whether out-of-domain instruction data and explanation-augmented training transfer to this clinical setting. Instruction tuning produces the strongest patient-utterance reference matching and improves classification accuracy. Reasoning-aware fine-tuning produces the strongest classification results among the LLaMA-3.1-8B variants. However, even the best models struggle to separate closely related dialogue acts, showing that broad conversational intent is easier to recognize than fine-grained communicative function. The corpus and benchmark make interaction…
PDF arXiv

Activity · 12 weeks

Fields · AI · updated 1h ago

Image segmentation

Found by the topic model: image segmentation, clinical reasoning, eeg foundation models.

161papers this week−28.8% vs last week

All papers · 1.1k With code · 4

Newest Most relevant

1k papers this month

Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.