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Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.

Open problems

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Topics in this field

image segmentation · volumetric · medical image403 papers55 this week
radiology report generation · medical vision language · vision language models127 papers34 this week
clinical reasoning · question answering · language models205 papers29 this week
patient history · clinical data · health records109 papers26 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers24 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Topics in this field

Active contributors · 90 days

Active contributors

Activity · 12 weeks

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Recent papers

All papers in Research

arXiv cs.LGSep 29
An Effective, Reliable, and Robust Framework for Human Activity Recognition Using Wearable Sensors
Nafees Ahmad, Ho-fung Leung, Muhammad Adil Abid, Sadia Shakil
Human Activity Recognition (HAR) through wearable sensors greatly improves the quality of human life through its multiple applications. For HAR, multi-sensor channel information is vital for optimal performance. Current work states that applying an attention neural network to prioritize discriminatory sensor channels helps the model classify activity more precisely. However, obtaining discriminatory information from multisensory channels is not always trivial, such as when collecting data from older hospitalized patients. In this context, existing HAR methods struggle to classify activities, particularly activities with similar natures. Moreover, HAR models predominantly suffer from overfitting due to the small size of available datasets, which leads to poor performance. Data augmentation (DA) is a viable solution to this problem. However, available DA methods have various drawbacks, including the possibility of being domain-dependent, resulting in distorted models for test sequences. To address these HAR problems, we propose a novel framework, ALAE-TAE-CutMix+, which focuses on two aspects. First, it enhances the latent information across each sensor channel and learns to…
PDF arXiv
arXiv cs.AISep 29
Automated Screw Planning for Reduced Pelvic Fractures Based on Statistical Shape Models and Deep Learning
Yang Gao, Sutuke Yibulayimu, Yanzhen Liu, Zian Zhao, Yudi Sang
Percutaneous iliosacral screw fixation is an important minimally invasive treatment for unstable pelvic fractures. Because the sacroiliac region has complex anatomy and narrow screw corridors, the accuracy and safety of screw placement directly affect surgical outcomes. Accurate and reliable preoperative screw planning is therefore essential to improve surgical success and reduce intraoperative risks. Conventional preoperative planning typically requires surgeons to determine screw trajectories through manual measurements, a labor-intensive process that depends on subjective clinical experience. To address these challenges, we propose a fully automated pipeline for preoperative iliosacral screw planning in patients with pelvic fractures. Using patient-specific three-dimensional anatomy, the pipeline automatically identifies safe screw corridors and generates individualized insertion trajectories to support clinical preoperative planning. We evaluated the proposed pipeline on 200 clinical cases of pelvic fractures. Compared with conventional manual measurements, the safety margin of the safe insertion corridors increased by 2% across the four screw types, the mean planning time…
PDF arXiv
arXiv cs.CVSep 29
You Cannot Recover What Was Never Measured: Quantifying the Information Ceiling of Ultra-Low-Field MRI Super-Resolution
Prathamesh Pradeep Khole, Shreya Handa, Utkarsh Gupta, Razvan Marinescu
Generative super-resolution models can turn portable 64 mT MRI into images that look like 3T scans, and the field evaluates them with PSNR, SSIM, and pixelwise uncertainty, most often on pairs built by synthetically degrading high-field images. Prior work acknowledges that these models hallucinate and that the problem is ill posed, but to our knowledge no study measures how much information about the individual subject the real low-field scan actually contains. We measure it. Using paired 64 mT and 3T scans of the same subjects from three public datasets, and a measurement protocol validated on tests whose correct answer is known in advance, we find that, judged over the whole brain, real 64 mT scans carry structure specific to the individual only down to approximately 3 to 4 mm half-pitch in plane, and coarser still through plane. Standard synthetic degradations preserve subject information roughly 1 mm beyond this ceiling, so models trained and benchmarked on synthetic pairs are evaluated on information that real scanners never record. We then test trained diffusion models and a publicly released external model on real paired acquisitions; 24 trained runs of five architectures…
PDF arXiv
arXiv q-bio.QMSep 29
Disease-level drug approval forecasting from trial-agnostic public data
Samir Townsley, Pagkratios Tagkopoulos, Ilias Tagkopoulos
Drug development is an expensive and lengthy process requiring developers to select drugs for human trials and diseases to target. Computational tools that can estimate before testing which drug-disease candidates are most likely to reach FDA approval could reduce development time and costs through early program advancement and disease prioritization. Yet existing approaches predict outcomes at a single level or stage or do not distinguish between disease outcomes for the same drug. We ask (1) whether FDA approval can be forecast for a drug-disease pair using only pre-clinical trial information, and (2) whether these forecasts can help prioritize diseases for the same drug. We built a cohort of 14,134 drug-disease pairs by reconstructing programs from ClinicalTrials.gov, extracting disease-level approvals from FDA label documentation, and enriching each pair with molecular, disease, ADMET, target, and pathway features. We divided the cohort into pre- and post-2019 programs and trained a classifier on pre-2019 data to predict FDA approval. On the post-2019 cohort (2,637 programs), the model would have prioritized a program that ultimately gained approval over one that did not…
PDF arXiv
arXiv cs.AISep 29
Geometry-Conditioned Fixed-Scaffold Encoders for Time-Warp Robust Sequence Retrieval
Cassandra Yang, Yufan Tang
Embedding-based retrieval is attractive for long sequence collections because each item can be encoded once and searched by nearest-neighbor ranking. The difficulty is that the objects being indexed are often observed under a noncanonical clock: cardiac cycles stretch with rate, speech changes with tempo, and sensor traces reach comparable states at different speeds. This paper studies a specific source of instability in patch-based encoders for this regime. If patch boundaries are chosen from signal geometry, then the tokenization can change under the same temporal deformation that the representation is expected to tolerate. We propose GeoPatch, a fixed-scaffold patch encoder that keeps token support independent of geometry and uses slope, curvature, acceleration, affine-residual, and confidence descriptors only as continuous conditioning variables. The design turns boundary variation into feature modulation: geometry can change the embedding through a controlled pathway, but it cannot change the number, order, or support of local tokens. We formalize this distinction through a mechanism-level stability analysis that separates boundary drift, affine timing variation,…
PDF arXiv
arXiv cs.LGSep 29
RAE-PPG: Duration-Grounded Retain-and-Extend Pretraining for PPG Foundation Models
Suyeong Lee, Hochang Lee, Seokyong Sheem, Daekyum Kim
Signal features derived from photoplethysmography (PPG) require different signal durations to characterize. Existing PPG foundation models treat duration as a pretraining or evaluation condition rather than using the different durations required by PPG features to organize self-supervision. We hypothesize that self-supervision should expand with signal duration, allowing a single encoder to progressively acquire additional features while preserving and reusing earlier learning. We introduce Retain-and-Extend PPG (RAE-PPG), which trains a single Transformer encoder successively on 10 s, 30 s, and 240 s inputs, adding supervision for signal features supported by each longer observation. The encoder is partitioned into duration-specific parameter groups, allowing later stages to reuse earlier groups while updating only the group assigned to the current stage. Selected earlier targets are reused to supervise later stages, encouraging the corresponding features to remain accessible in longer-input representations. Direct decoding from the final encoder shows that earlier features remain recoverable from longer-input representations, while later-stage features show higher mean decoding…
PDF arXiv

Papers

Topics in this field

image segmentation · volumetric · medical image403 papers55 this week
radiology report generation · medical vision language · vision language models127 papers34 this week
clinical reasoning · question answering · language models205 papers29 this week
patient history · clinical data · health records109 papers26 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers24 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Active contributors · 90 days

Recent papers

All papers in Research

arXiv cs.LGSep 29
An Effective, Reliable, and Robust Framework for Human Activity Recognition Using Wearable Sensors
Nafees Ahmad, Ho-fung Leung, Muhammad Adil Abid, Sadia Shakil
Human Activity Recognition (HAR) through wearable sensors greatly improves the quality of human life through its multiple applications. For HAR, multi-sensor channel information is vital for optimal performance. Current work states that applying an attention neural network to prioritize discriminatory sensor channels helps the model classify activity more precisely. However, obtaining discriminatory information from multisensory channels is not always trivial, such as when collecting data from older hospitalized patients. In this context, existing HAR methods struggle to classify activities, particularly activities with similar natures. Moreover, HAR models predominantly suffer from overfitting due to the small size of available datasets, which leads to poor performance. Data augmentation (DA) is a viable solution to this problem. However, available DA methods have various drawbacks, including the possibility of being domain-dependent, resulting in distorted models for test sequences. To address these HAR problems, we propose a novel framework, ALAE-TAE-CutMix+, which focuses on two aspects. First, it enhances the latent information across each sensor channel and learns to…
PDF arXiv
arXiv cs.AISep 29
Automated Screw Planning for Reduced Pelvic Fractures Based on Statistical Shape Models and Deep Learning
Yang Gao, Sutuke Yibulayimu, Yanzhen Liu, Zian Zhao, Yudi Sang
Percutaneous iliosacral screw fixation is an important minimally invasive treatment for unstable pelvic fractures. Because the sacroiliac region has complex anatomy and narrow screw corridors, the accuracy and safety of screw placement directly affect surgical outcomes. Accurate and reliable preoperative screw planning is therefore essential to improve surgical success and reduce intraoperative risks. Conventional preoperative planning typically requires surgeons to determine screw trajectories through manual measurements, a labor-intensive process that depends on subjective clinical experience. To address these challenges, we propose a fully automated pipeline for preoperative iliosacral screw planning in patients with pelvic fractures. Using patient-specific three-dimensional anatomy, the pipeline automatically identifies safe screw corridors and generates individualized insertion trajectories to support clinical preoperative planning. We evaluated the proposed pipeline on 200 clinical cases of pelvic fractures. Compared with conventional manual measurements, the safety margin of the safe insertion corridors increased by 2% across the four screw types, the mean planning time…
PDF arXiv
arXiv cs.CVSep 29
You Cannot Recover What Was Never Measured: Quantifying the Information Ceiling of Ultra-Low-Field MRI Super-Resolution
Prathamesh Pradeep Khole, Shreya Handa, Utkarsh Gupta, Razvan Marinescu
Generative super-resolution models can turn portable 64 mT MRI into images that look like 3T scans, and the field evaluates them with PSNR, SSIM, and pixelwise uncertainty, most often on pairs built by synthetically degrading high-field images. Prior work acknowledges that these models hallucinate and that the problem is ill posed, but to our knowledge no study measures how much information about the individual subject the real low-field scan actually contains. We measure it. Using paired 64 mT and 3T scans of the same subjects from three public datasets, and a measurement protocol validated on tests whose correct answer is known in advance, we find that, judged over the whole brain, real 64 mT scans carry structure specific to the individual only down to approximately 3 to 4 mm half-pitch in plane, and coarser still through plane. Standard synthetic degradations preserve subject information roughly 1 mm beyond this ceiling, so models trained and benchmarked on synthetic pairs are evaluated on information that real scanners never record. We then test trained diffusion models and a publicly released external model on real paired acquisitions; 24 trained runs of five architectures…
PDF arXiv
arXiv q-bio.QMSep 29
Disease-level drug approval forecasting from trial-agnostic public data
Samir Townsley, Pagkratios Tagkopoulos, Ilias Tagkopoulos
Drug development is an expensive and lengthy process requiring developers to select drugs for human trials and diseases to target. Computational tools that can estimate before testing which drug-disease candidates are most likely to reach FDA approval could reduce development time and costs through early program advancement and disease prioritization. Yet existing approaches predict outcomes at a single level or stage or do not distinguish between disease outcomes for the same drug. We ask (1) whether FDA approval can be forecast for a drug-disease pair using only pre-clinical trial information, and (2) whether these forecasts can help prioritize diseases for the same drug. We built a cohort of 14,134 drug-disease pairs by reconstructing programs from ClinicalTrials.gov, extracting disease-level approvals from FDA label documentation, and enriching each pair with molecular, disease, ADMET, target, and pathway features. We divided the cohort into pre- and post-2019 programs and trained a classifier on pre-2019 data to predict FDA approval. On the post-2019 cohort (2,637 programs), the model would have prioritized a program that ultimately gained approval over one that did not…
PDF arXiv
arXiv cs.AISep 29
Geometry-Conditioned Fixed-Scaffold Encoders for Time-Warp Robust Sequence Retrieval
Cassandra Yang, Yufan Tang
Embedding-based retrieval is attractive for long sequence collections because each item can be encoded once and searched by nearest-neighbor ranking. The difficulty is that the objects being indexed are often observed under a noncanonical clock: cardiac cycles stretch with rate, speech changes with tempo, and sensor traces reach comparable states at different speeds. This paper studies a specific source of instability in patch-based encoders for this regime. If patch boundaries are chosen from signal geometry, then the tokenization can change under the same temporal deformation that the representation is expected to tolerate. We propose GeoPatch, a fixed-scaffold patch encoder that keeps token support independent of geometry and uses slope, curvature, acceleration, affine-residual, and confidence descriptors only as continuous conditioning variables. The design turns boundary variation into feature modulation: geometry can change the embedding through a controlled pathway, but it cannot change the number, order, or support of local tokens. We formalize this distinction through a mechanism-level stability analysis that separates boundary drift, affine timing variation,…
PDF arXiv
arXiv cs.LGSep 29
RAE-PPG: Duration-Grounded Retain-and-Extend Pretraining for PPG Foundation Models
Suyeong Lee, Hochang Lee, Seokyong Sheem, Daekyum Kim
Signal features derived from photoplethysmography (PPG) require different signal durations to characterize. Existing PPG foundation models treat duration as a pretraining or evaluation condition rather than using the different durations required by PPG features to organize self-supervision. We hypothesize that self-supervision should expand with signal duration, allowing a single encoder to progressively acquire additional features while preserving and reusing earlier learning. We introduce Retain-and-Extend PPG (RAE-PPG), which trains a single Transformer encoder successively on 10 s, 30 s, and 240 s inputs, adding supervision for signal features supported by each longer observation. The encoder is partitioned into duration-specific parameter groups, allowing later stages to reuse earlier groups while updating only the group assigned to the current stage. Selected earlier targets are reused to supervise later stages, encouraging the corresponding features to remain accessible in longer-input representations. Direct decoding from the final encoder shows that earlier features remain recoverable from longer-input representations, while later-stage features show higher mean decoding…
PDF arXiv

Activity · 12 weeks

Fields · AI · updated 54m ago

Image segmentation

Found by the topic model: image segmentation, clinical reasoning, eeg foundation models.

183papers this week−13.3% vs last week

All papers · 1.1k With code · 4

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1k papers this month

Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.