Longitudinal Retinal Vascular Remodeling in Myopic Children Treated with Orthokeratology or Defocus Lenses: A Two-Year Comparative Study

Zhihao Zhao, Yinzheng Zhao, Jie Zhang, Huiqin Jiang, Yanyu Shangguan +5

Purposes: To characterize longitudinal retinal vascular changes in myopic children treated with orthokeratology (OK) or multifocal defocus lenses (Defocus) and to examine their association with axial elongation. Methods: In this retrospective cohort study, 43 myopic children underwent comprehensive clinical examination and fundus photography at baseline, 12 months, and 24 months. Axial length (AL) and spherical equivalent refraction (SER) were recorded at baseline, 6, 12, and 24 months. An automated segmentation model extracted vascular parameters, main vessel angle (MA), branching angle (BA), bifurcation edge angle (BEA), crossover point (COP), and terminal vessel count (TVC). Repeated-measures ANOVA assessed temporal changes. Pearson or Spearman correlations evaluated associations between AL and vascular metrics. Results: Over 24 months, the OK group exhibited significantly slower axial elongation than the Defocus group (0.214 mm and 0.522 mm, p < 0.01). In the OK group, MA and BA decreased modestly, BEA in arteries declined gradually, but COP and TVC remained relatively stable. The Defocus group demonstrated more pronounced decreases in MA and BA, an increase in BEA, and…