A generalizable structural brain MRI foundation model built through dual-priority federated pretraining

Zhen Yu, Yang Liu, Xiahai Zhuang, Qingchao Chen

Foundation models hold promise for generalizable analysis of structural brain magnetic resonance imaging (MRI) across development, aging and disease. However, existing models are typically built through centralized pretraining on pooled data, despite privacy and governance constraints. Such pooling optimization can overemphasize cohort size and overlook complementary information from smaller, specialized cohorts. Here we present BrainFedFM, a structural brain MRI foundation model federatively pretrained on 164,707 three-dimensional scans drawn from diverse real-world data distributions and organized across 42 federated sites. BrainFedFM uses dual-priority federated pretraining, coupling spatial-priority masking at each site with site-priority aggregation at the server to emphasize informative anatomical regions locally and prioritize site contributions globally. Across 20 downstream datasets spanning 17 classification, regression and segmentation tasks, BrainFedFM achieved the state-of-the-art performance (mean rank 1.68, 50\% gain) across seven models, including four centralized foundation models, while showing particularly consistent advantages in classification and regression…