Autoresearch in Mixed-Integer Linear and Nonlinear Programming

Yuwei Gu, Yaoxin Wu, Tong Guo, Wen Song, Zhiguang Cao

Despite recent progress in autoresearch, applying it to practical operations research problems, typically formulated as NP-hard mixed-integer linear or nonlinear programs (MILPs or MINLPs), remains challenging because effective research requires systematically managing competing ideas and long-horizon experimental trajectories. We introduce AutoMIP, a reusable agent skill for organizing long-horizon autoresearch in mixed-integer programming through idea pooling and algorithm tree search. AutoMIP maintains a persistent pool of complementary candidate ideas while organizing executable experiments into an algorithm tree, enabling the agent to preserve unexplored hypotheses, refine promising algorithms, and switch to alternative methodological directions based on historical states. On MILP and MINLP benchmark cohorts, AutoMIP achieves the highest final success rates among the evaluated autoresearch frameworks. On MIPLib, AutoMIP discovers new best solutions for 31 of 60 instances, surpassing existing autoresearch frameworks. On MINLPLib, it achieves new best solutions for 52 of 60 instances. Ablation studies further demonstrate the complementary contributions of idea pooling and…