LLM-Assisted Discovery of Typed Semantic Links for Ontology Network Construction

Nouha Hayouni, Sheeba Samuel, Alsayed Algergawy

Constructing typed, justified semantic links between ontologies is essential for enabling interoperability across heterogeneous and interdisciplinary knowledge domains. However, manually curating such links is difficult to scale. To address this challenge, we propose an end-to-end framework for ontology network construction that automates the discovery and generation of both intra-domain and inter-domain relationships. Our approach combines domain-adapted DistilBERT embeddings for dense contextual representation, clustering-based pre-filtering to reduce the candidate search space, and GPT-4o-driven relationship generation via iterative prompt engineering to produce semantically rich, interpretable links. Applied to ReproduceMeON - a network of 33 ontologies spanning machine learning, microscopy, computational science, and experimental workflow - the pipeline reduces approximately 800k raw concept pairs to 95k high-quality candidates. Human expert validation of 429 generated relationships by two independent annotators yields an overall precision of 80.19% (91.49% on high-certainty annotations) and an F1 of 0.890, with substantial inter-annotator agreement. Comparative experiments…