PharmAgent: Constraint-Aware Search with Frozen Language Models for Molecular Optimization

Nihui Shao, Guanxing Chen, Jilong Shi, Zhengyang Bai, Haohuai He +4

Molecular optimization must improve target activity and satisfy developability constraints within limited evaluation budgets. Classical methods require tailored rules or training to incorporate chemical instructions and property feedback. Frozen language models can condition edits on this information, but need explicit constraint control and relevant experience. We therefore present PharmAgent, a constraint-aware molecular search method driven by adaptive external state. Its Lagrangian controller translates violations in accepted states into accumulated constraint pressure, keeping this history separate from current property measurements. Structure-indexed replay complements this feedback with relevant evaluated transitions that guide subsequent proposals. As a curriculum progressively activates constraints, candidates and the incumbent are compared under the same current objective, and the accepted state determines the next multiplier update. We derive an exact identity that characterizes how accepted-state violations accumulate in the controller's multipliers. Across five tasks with five independent runs, PharmAgent achieves a summed area under the target-score curves (AUC) of…