Deep Learning for Longitudinal Medical Imaging: A Scoping Review

Francesca Mussa, Divyanshu Tak, Atlas H. Avval, Sarah Brueningk, Ray H. Mak +3

Longitudinal medical imaging analysis is a cornerstone of modern medical practice and patient care. Deep learning applied to longitudinal imaging offers wide potential to enhance diagnosis and track disease progression by capturing spatial changes over time. With major advances in single-timepoint deep learning for imaging, there has been growing interest in longitudinal image analysis, given its increased clinical relevance, though technical challenges remain. Several recent innovations may lead to a new era of multi-timepoint image evaluation, yet the scientific landscape, recent progress, and areas of need remain under-characterized. To address this gap, we conducted a scoping review of deep learning methodologies applied to longitudinal medical imaging, yielding 102 studies published between 2018 and 2025. Neurological disorders (48%) and ophthalmic conditions (12%) were the most common clinical applications, with MRI serving as the predominant imaging modality (67%). Sequential feature modeling approaches combining convolutional neural networks (CNNs) with temporal models (LSTM/RNN) were the most frequent methodology (40%), followed by direct feature aggregation across…