LabInstruct: Benchmarking Situated Instructional Video Generation for Lab Procedures

Yuming Fu, Weijia Wu, Jing Chen, Jiahao Tang, Feifei Chen +3

Self-driving laboratories (SDLs) aim to automate the full experimental loop, from scientific decision-making to physical execution. Ideally, AI-generated plans could be carried out directly by robotic systems, but reliable automation remains difficult in complex, open-world laboratory environments, where experiments often involve fine-grained manipulation, long-horizon procedures, and substantial variation across tasks and setups. Humans therefore remain an important execution interface between AI-generated plans and physical experiments, creating a need for clear and effective human-facing experimental guidance. Because laboratory procedures are inherently visual, spatial, and dynamic, video is particularly well suited to communicating apparatus configurations, manipulation actions, temporal dependencies, and state changes. Recent advances in video generation now make it possible to synthesize experimental demonstrations directly from an initial workspace image and a natural-language instruction. However, whether such models can reliably communicate real laboratory procedures has not been systematically studied. We introduce LabInstruct, a benchmark for situated instructional…