NoduleFlow: Automatic 3D Lung Nodule Detection and Segmentation

Giulia Romoli, Filippo Ruffini, Francesco Di Feola, Valerio Guarrasi, Matteo Tortora +1

Low dose Computed Tomography (CT) is the standard imaging modality for lung cancer screening. On CT scans, lung cancer typically manifests as pulmonary nodules, whose manual identification is time-consuming and prone to observer variability, image quality limitations, and suboptimal reading conditions. Moreover, subtle temporal changes are often difficult to quantify reliably in CT scans from the same patient across follow-up examinations. Deep learning-based approaches for the automatic detection and segmentation of lung nodules have demonstrated improved accuracy and efficiency. However, most existing approaches provide only coarse region-of-interest localisation, rely on prior lesion annotations or human supervision, or treat detection and segmentation as separate tasks. In this work, we present NoduleFlow, a framework for lung nodule detection, classification, and segmentation directly from series of CT volumes. Our proposal consists of four interconnected modules and operates in an automated manner at inference time, without requiring prior lesion annotations, manual initialisation, or region-of-interest pre-selection. We further investigate whether nodule localization…