Denoise X: Self-Supervised U-Net for Quantum Mottle Suppression in Chest Radiography

Parth Giramkar, Aryan Patle, Vanita Kshirsagar

Deep learning for medical image restoration is often constrained by the need for paired training data. Acquiring perfectly registered clean-noisy radiographs in vivo is impractical due to patient motion and radiation-dose limits. To address this, we employ a self-supervised Noise2Noise paradigm that trains on independently corrupted observations without paired clean images. We propose Denoise X, a lightweight self-supervised U-Net model (7.79M parameters) for suppressing quantum mottle and electronic readout noise in low-dose chest radiographs. It is trained on the NIH ChestX-ray14 dataset (112,120 images) using a stochastic Poisson-Gaussian noise simulator. Zero-shot evaluation on the unseen Montgomery County dataset achieved a PSNR of 36.09 dB and SSIM of 0.8806, outperforming the Bilateral filter while preserving high-frequency anatomical details. Using patch-wise inference, Denoise X processes native-resolution chest radiographs in ~2.2 s per image on a Tesla P100 GPU. Cross-domain evaluation on the Shenzhen dataset achieved 36.44 dB PSNR and 0.9099 SSIM, showing strong generalization. For resource-constrained deployment, the model was converted into a 31.16 MB ONNX model for…