GliomaINK: A Tumor and Anatomy Conditioned Flow Matching Framework for 3D MRI Sequence Synthesis in Glioma Patients

Moinak Bhattacharya, Annie Singh, Mohammad Chaudhry, Prateek Prasanna, Gagandeep Singh

Background: Incomplete multiparametric MR examinations limit glioma characterization and downstream AI tools. Generative models can synthesize missing MRI sequences, but anatomical structure and clinically relevant tumor features are challenging to preserve. We propose GliomaINK, an anatomy-guided conditional flow matching framework for cross-sequence 3D brain MRI synthesis. Methods: A 3D SwinUNETR predicted the conditional velocity field while an auxiliary topology-preserving loss encouraged structural consistency. The model was trained on 1,083 patients from the BraTS-AG dataset and independently tested on an in-house clinical cohort. Downstream tasks include image quality, tumor segmentation, IDH1 mutation-status prediction, and overall survival prediction. Two radiologists independently evaluated the anatomical fidelity, pathological representation, and overall image quality of the synthesized images. Results: GliomaINK exhibited the highest PSNR across all six MRI translation directions in both evaluation cohorts. In the BraTS-AG test set, the PSNR reached $25.64\pm0.55$ dB for the T2W-to-T1C synthesis, compared with $13.78\pm0.32$ dB for Pix2Pix and $18.90\pm0.53$ dB for…