Enhancing analytical photon transport in turbid media through physics-guided neural network corrections

Guojun Tang, Paul D. Teal, Alexander Doronin

Analytical methods provide rapid and computationally efficient predictions of light transport in turbid media, making them attractive for real-time and inverse applications. However, their accuracy is limited by the approximations and assumptions used to obtain tractable solutions. On the other hand, Monte Carlo (MC) simulation is widely regarded as the "gold standard" for modeling light transport in turbid media, but its high computational cost limits its use in applications requiring repeated forward evaluations. Here, we introduce a physics-guided residual learning framework that combines the computational efficiency of analytical modeling with the accuracy of MC simulation. As a representative case study, we consider the diffusion approximation (DA), which can exhibit systematic errors under relatively strong absorption, weak scattering, and imperfect boundary treatment. Given the absorption coefficient, scattering coefficient, and anisotropy factor, the corresponding DA prediction is incorporated as a physical prior, while the network learns only the residual between the analytical prediction and the MC reference. Across the evaluated optical-property range, the proposed…