ReSeg: Retraining-free segmentation of abdominal organs via generalizable semantic representation learning

Derong Yu, Guoyan Zheng

Abdominal organ segmentation is essential in modern medical applications. While existing deep learning approaches demonstrate promising performance, their heavy reliance on large-scale image data raises concerns over generalization capability and privacy risks. This motivates the development of generalizable segmentation training paradigms based on domain-randomized image synthesis, facilitating generalization across unseen real image domains. However, existing paradigms either suffer from limited segmentation performance when applied to abdominal organs, or require dataset-specific finetuning. To address these limitations, we propose ReSeg, a novel two-stage retraining-free framework for domain-agnostic zero-shot abdominal organ segmentation. At the first stage, our organ-agnostic synthetic data-driven pretraining approach exploits semantically and visually diverse synthetic images generated by a dedicated data engine to optimize a Generalizable Semantic Representation Network (GSRNet). The network is thereby capable of learning semantic features robust against variations in anatomical structure, imaging contrast, resolution and spatial context, which provide universal…