When Reconstruction Is Not Enough: Doubly Robust Counterfactual and Interventional Mediation Analysis with Learned Multimodal Representations

Cong Cao

Learned representations of high-dimensional multimodal health records are increasingly used to adjust for confounding, yet they are usually trained to reconstruct the data rather than preserve the information that causal identification requires. We study counterfactual outcomes under alternative treatments, including phenotype-specific effects and patient-level counterfactual risk profiles of the kind digital twins provide, and interventional direct and indirect effects under exposure-induced intermediate confounding. We give conditions under which a representation preserves identification and show that interventional mediation is more demanding than counterfactual comparison. We prove that no covariate-only training objective, whether reconstruction, contrastive, or physics-informed, can certify that a representation is sufficient, and that, in a linear structural model, a representation can lose arbitrarily little reconstruction accuracy yet induce arbitrarily large bias. We decompose the error of cross-fitted doubly robust estimators into a first-order representation bias, which neither double robustness nor cross-fitting removes, and a second-order remainder of…