O2D-MedNet: An Optimization-Aware Dual-Domain Framework for Robust Medical Image Segmentation

Shipeng Hu, Miaohui Wang, Jing Qin, Sukun Tian, Yuchun Sun

Medical image segmentation (MIS) remains challenging due to composite degradations and multi-scale geometric variations, which jointly impair lesion-background separability, structural consistency, and optimization stability. Existing single-stream frameworks entangle heterogeneous cues within a single representation pathway, while hybrid-stream approaches often rely on generic or static fusion, limiting effective coordination across domains and failing to explicitly address optimization instability. To overcome these limitations, we propose a new optimization-aware dual-domain framework for MIS (O2D-MedNet). First, a degradation-aware dualdomain interaction (DDI) module integrates Fourier - and Wavelet-domain features to suppress degradation-sensitive responses while preserving structural and fine-detail information. Second, a cross-backbone contour-guided fusion (CGF) module enables selective interaction between CNN-based local detail modeling and visual state-space-based global structure modeling, improving boundary accuracy and representation consistency. Third, a gradient-context optimization (GCO) strategy stabilizes training by adaptively adjusting learning dynamics based…