Evaluating Federated Vision-Language and Vision-Only Models for Privacy-Aware Breast Cancer Imaging

Malithi Mithsara Wanniarachchi Kankanamge, Ning Yang, Sree Bash Debnath, Md Zobaer Islam, Abdur R. Shahid

Artificial intelligence (AI) shows promise for breast imaging, but limited labeled data, institutional data fragmentation, and privacy concerns hinder centralized training. We investigate a privacy-aware federated learning framework combining pretrained vision-language models (VLMs) with client-level differential privacy. We compare general-purpose CLIP models, biomedical BiomedCLIP, and an ImageNet-pretrained ViT-B/16 baseline on two public breast imaging datasets, with and without differential privacy. We also evaluate a CLIP ViT-B/16 ablation that removes the text pathway. Evaluation includes patient-level ROC-AUC with bootstrap 95% confidence intervals, baseline comparisons, threshold sensitivity, inter-model agreement, and communication cost. Under federated learning, all five models achieve high normal-versus-sick discrimination (ROC-AUC: 0.940-0.990). However, acquisition year alone achieves 0.974 on the same test partition, raising concerns about confounding rather than genuine pathology recognition. Benign-versus-malignant discrimination remains uncertain (ROC-AUC: 0.504-0.637), with all confidence intervals including 0.50. Removing the text pathway preserves…