OpenGray: a benchmark for evaluating the decisions of radiotherapy planning agents

Humza Nusrat, Kundan Thind

Background and purpose: Radiotherapy planning agents based on large language models (LLMs) decide when to submit a plan or request review but are evaluated mainly by dose. This study developed OpenGray, a benchmark of planning tasks with known correct decisions. Materials and methods: OpenGray adds tasks with known answers to the OpenKBP-Opt head-and-neck dataset, including two contradictions with dose goals proven incompatible and a feasible control with a stored plan meeting every hard goal. Four systems, from a rule-based planning script to a full LLM agent, were evaluated on 30 patients, the LLM-based ones with a commercial (Terra) and a local (Ministral 3 8B) LLM. Decisions, achieved dose, problem recognition, and technical failures were recorded and also read from logs of 39 stereotactic radiosurgery runs of SAGE, a clinical LLM agent. Results: With Terra, the script preceded by an LLM review and the full agent had decision accuracies of 95.4% and 92.1%, respectively, yet escalated only 50% (95% confidence interval, 25-75%) and 25% (10-40%) of overlap contradictions, which required arithmetic on the anatomy. All four systems submitted every feasible control, but 24% of…