MEMIG: Self-evolving Memory Construction for Antibody Optimization

Yunhui Jang, Zach Wang, Jai Doshi, Kangway Chuang, Sidney Lisanza +1

Memory has become central to self-evolving LLM agents, which store and retrieve experience from past rollouts to guide future decisions. Existing systems represent this experience as free-form natural language and maintain it by rewriting, which fits tasks whose experience is narratable. However, in scientific discovery and optimization, experience is often a quantity measured by an oracle under a specific context. Rewriting it as text leaves no index for where a record should be, replaces a measurement with a description, and cannot express how interventions interact. To address this, we argue that agent memory for biomolecule optimization should instead be indexable, quantitative, and structured, and we introduce MEMIG. This memory construction framework realizes these three properties. In detail, MEMIG addresses each insight with a domain-grounded identifier and accumulates the quantitative effect measured by a property oracle, so that updates remain local and retrieval becomes an exact lookup. Next, MEMIG connects insights whose interventions are applied together and measures their epistasis by decomposing each evaluated set. Our results show that MEMIG improves performance…