GazeRIB: Systematic Evaluation of Multi-Reader Gaze-Guided Chest X-ray Learning

Nattakorn Kittisut, Roy M. Gabriel, Marly van Assen, Mohammadreza Zandehshahvar, Carlo N. De Cecco +2

Radiologists' visual attention can supervise medical image learning, but how reader panel composition affects its value remains untested. We evaluated GazeRIB (Gaze-guided Radiologist-Informed Blackout), which masks unviewed regions during training and uses unmasked images at inference. Eight experts repeatedly read the same 80 chest X-rays (CXRs). We compared individual readers with three-, five- and eight-reader panels across seven architectures and 10 seeds, evaluating 910 models on a separate 2,897-CXR cohort for four-class severity prediction. Every panel improved macro F1 over the no-gaze baseline by 5.33-7.47 percentage points (pp; Bonferroni-adjusted p < 0.007); no individual reader reached significance on this endpoint. Three readers captured 73-80% of the eight-reader gain in macro F1, the area under the receiver-operating-characteristic curve (ROC-AUC) and the area under the precision-recall curve (AU-PRC). On external validation without retraining, all four panels improved ROC-AUC on SIIM-FISABIO-RSNA by +1.93 to +4.24 pp (p <= 0.004); on MIMIC-Eye no panel differed significantly from baseline, whereas the single-reader average declined (-1.40 pp, p = 0.008). Reader…