PRIME: Predictive Routing of Interventions by Modeling Effects for Scientific Ideation

Fengxian Ji, Xie Yu, Zhexuan Cui, Yuke Li, Zirui Song +6

Feedback-driven iteration is widely used to improve LLM-generated scientific ideas, but existing systems either leave revision decisions implicit in generation, align revisions with feedback-localized weaknesses, or restrict action selection to system-specific operations. This is problematic because problems, hypotheses, and solutions are interdependent: the location where a weakness manifests does not itself determine the revision scope that will produce a better successor. We term this phenomenon diagnosis-intervention mismatch. We introduce Predictive Routing of Interventions by Modeling Effects (PRIME), a plug-and-play feedback-to-revision decision layer for existing scientific ideators. PRIME operates in three stages: (1) Structural Attribution interprets feedback over the problem-hypothesis-solution structure without fixing a revision target; (2) Counterfactual Routing constructs alternative scope-conditioned interventions and compares their projected successor utility and risks through lightweight rollouts; and (3) Intervention Execution compiles the selected intervention into an ordered generator-facing plan with semantic actions, preservation constraints, and dependency…