Measure Before You Repair: An Explainable Agent for Blind Restoration of Multi-Artifact 3-D MRI

Necati Sefercioglu, Mehmet Ozan Unal, Metin Ertas, Altan Cakir, Isa Yildirim

A brain MRI scan can carry an unknown mix of artifacts, so restoration has to be blind, yet most deep-learning methods are built to correct one known artifact. We present Dx-Rx, an agent in which a multimodal large language model (MLLM) measures suspected artifacts before it repairs them. To our knowledge, it is the first agent to restore whole 3-D MRI volumes, whereas earlier MRI agents restore 2-D slices. In a loop, it looks at slices of the 3-D volume, calls five diagnostic tools (noise, spike, ghosting, bias field, motion) and four restoration tools in any order it chooses, checks each repair, can return to any earlier version to change the order, and ends with a radiology-style report of its diagnostic reasons, the repairs it applied and their results. We simulated up to five artifacts on 148 whole 3-D T1-weighted volumes, at levels calibrated to radiologists' grades of real scans. An MLLM that only looked at the image, as earlier MRI agents do, removed at most 19.7 % of the artifact error. With the best of five MLLMs, Dx-Rx removed a mean 64.5 %, nearly matching the 64.6 % of the same tools given the ground-truth artifacts, which are never known for a clinical scan. With…