A Geometry-Guided Feature-Space Framework for Interpretable Unsupervised 4D-STEM Analysis of Complex Multiphase Materials

Arda Genc, Daniel A. Bolden, Albert Nguyen, Daniel S. Gianola, Ravit Silverstein

Rapid, high-fidelity analysis of four-dimensional scanning transmission electron microscopy (4D-STEM) datasets from heterogeneous materials remains challenging because coexisting phases, orientation variants, local strain gradients, and intrinsic TEM thin-foil effects produce complex, overlapping diffraction signatures. Here, we present a machine-learning (ML) framework that combines physics-informed geometric descriptors with weighted high-dimensional embeddings to identify latent structural patterns with minimal prior knowledge. By constructing a regularized descriptor space before embedding and density-based clustering, the method improves cluster stability, suppresses noise-driven fragmentation, and reduces sensitivity to embedding hyperparameters. Spatial weighting produced the largest stability gain, increasing median cluster persistence from 0.04 to 0.55 while reducing the noise fraction from approximately 22% to 0%. Rotation weighting increased DBCV from 0.80 to 0.92, although the noise fraction rose from 0.2% to 1.0%, highlighting a trade-off between improved density separation and noise rejection. We validate the framework on two benchmark systems: Si/Si$_x$Ge$_{1-x}$…