The Average Patient: Do Simulated Psychiatric Patients Answer Like Real People?

Weixiang Sun, Zehong Wang, Kaiwen Shi, Hong Huang, Colby Nelson +2

Language models are used as simulated psychiatric patients to train clinicians and evaluate AI therapists, and are judged by plausibility or total scores. We give a framework for simulated respondents: an information budget bounds how much simulated patients can differ, and an average-patient hypothesis, that a model answers each item at the level typical of the named condition and severity, implies little variation, a full profile of the condition's typical symptoms and totals at or above the top of the stated severity band. We examine these implications at matched totals on item-level data from eight human samples, including a clinical and an instructed-feigning sample. Across 17 models, simulated patients vary 1.5 to 11 times less than real respondents with the same total and on most questionnaires endorse nearly every symptom at a middling level; on the PHQ-9 their symptoms covary less like real ones. People, honest or feigning, answer "not at all" about as often as genuine patients with the same totals, and more often than every model. Single answers are highly concentrated, and prompt changes, published personas, larger models and reasoning reduce the pattern without…