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Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.

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Topics in this field

image segmentation · volumetric · medical image403 papers50 this week
radiology report generation · medical vision language · vision language models127 papers33 this week
clinical reasoning · question answering · language models205 papers25 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers23 this week
patient history · clinical data · health records109 papers22 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Topics in this field

Active contributors · 90 days

Active contributors

Activity · 12 weeks

Activity

Recent papers

All papers in Research

arXiv q-bio.QMSep 28
Uncertainty Quantification in Cardiac Model Personalisation from Ultrafast Ultrasound
Camilla Ferrario, Maelys Venet, Olivier Villemain, Maxime Sermesant
Cardiac model personalisation requires inferring mechanical parameters that are not directly measurable in vivo. Ultrafast ultrasound shear wave elastography (SWE) enables non-invasive tracking of myocardial stiffness dynamics over the cardiac cycle, providing a target for personalisation. However, mapping these observations to subject specific model parameters remains ill-posed, as multiple parameter sets can reproduce the same stiffness dynamics. We formulate SWE-informed personalisation as a statistical inference problem using simulation-based inference (SBI). Using a subject-adapted 0D cardiovascular model and neural posterior estimation, we estimate model-conditional posterior distributions over active stiffness scale k0, contraction rate kATP, and relaxation rate kSR, conditioned on SWE-derived curve features and subject specific context. Among six healthy volunteers, four passed objective prior-support diagnostics and were retained for quantitative posterior analysis. Curve-level RMSE against the observed SWE target decreased from 12.61 $\pm$ 5.55 kPa for the prior predictive median to 1.14 $\pm$ 0.38 kPa for the posterior predictive median, an 89.7 $\pm$ 4.2% reduction.…
PDF arXiv
arXiv cs.CVSep 28
From UNI2-h to ConvNeXt-T: Lightweight Nuclei Instance Segmentation via Knowledge Distillation
Wenyan Li
Nuclei instance segmentation is a core task in digital pathology, yet high-accuracy models rely on large vision transformer (ViT) encoders whose inference speed cannot meet real-time clinical demands. We propose a lightweight scheme that distills the UNI2-h pathology foundation model into a ConvNeXt-Tiny student (Ours-T, 34.7M parameters, 1/20 of the teacher) via output-level knowledge distillation. Ours-T achieves an mPQ of 0.519 on PanNuke (98.8% of the teacher), a zero-shot bPQ of 0.668 on MoNuSeg, and an inference speed of 634.3 img/s, requiring only 0.045 s for full-resolution 1024^2 analysis (21.8x speedup). Experiments further show that multi-scale gated convolution (MALA) yields no gain under ViT encoders, and output-level distillation alone suffices for efficient knowledge transfer.
PDF arXiv
arXiv cs.CVSep 28
CarveMix-RC: Addressing Rare-Class Imbalance Through Lesion-Aware Synthetic Augmentation for Brain Metastasis Segmentation
Md Shibly Sadique, Md Fayaz Bin Hossen, Michael L. Evans, Walia Farzana, Asfaqur Rahman +2
Accurate segmentation of post-treatment brain metastases is essential for treatment planning, longitudinal disease monitoring, and quantitative assessment of therapeutic response. The BraTS-MET 2026 Task 1 challenge introduces a clinically relevant segmentation problem involving four anatomically distinct tumor subregions: non-enhancing tumor core (NETC), surrounding non-enhancing FLAIR hyperintensity (SNFH), enhancing tumor (ET), and the resection cavity (RC). Among these, RC segmentation is particularly challenging because of its low prevalence, heterogeneous postoperative appearance, and lesion-wise evaluation protocol, leading conventional segmentation networks to prioritize dominant tumor classes during optimization. The proposed nnU-Net-based framework explicitly addresses RC segmentation through four complementary components: (i) RC-weighted Dice and Cross-Entropy optimization to alleviate class imbalance, (ii) anatomically consistent cavity augmentation to increase the diversity of postoperative cavity appearances, (iii) a residual encoder architecture for enhanced multi-scale feature learning, and (iv) lesion-aware morphological post-processing to suppress false-positive…
PDF arXiv
arXiv cs.LGSep 28
A Multimodal Autonomic Sensing Framework for Objective Assessment of Patient Responses to Dental Pulp Stimulation
Youngsun Kong, Yubin Choi, Dongjin Song, Dong-Guk Shin, I-Ping Chen +1
Patient responses to dental pulp testing, ranging from no sensation to intense pain, provide important information for assessing pulp status in endodontic diagnosis. However, pain is a subjective sensory and emotional experience that varies considerably across individuals and can be difficult to communicate. We investigated whether complementary autonomic signals could support objective assessment of responses during dental examination. Forty-nine patients underwent cold pulp testing, yielding no-response, mild-response, and intense-response conditions. The framework integrated ECG-derived skin nerve activity (SKNA) and R-R intervals (RRI), together with electrodermal activity (EDA), using temporal convolutional network encoders with attention-based mid-level fusion. Individual baseline signals and subject-level covariates, including anxiety scores and biological sex, were also incorporated. The framework achieved 80.2% balanced accuracy, 75.2% sensitivity, and 85.2% specificity for binary classification of no response versus mild or intense response. For three-class classification, it achieved 60.0% balanced accuracy and a 58.8% macro-averaged F1 score. Ablation and…
PDF arXiv
arXiv cs.CVSep 28
Style-Driven Data Synthesis and Degradation-Aware Enhancement for Ultrasound Image Restoration
Yu-Kai Wang, Chun-Xin Tan, Manh-Hung Nguyen, Ching-Chun Huang
Low-cost handheld ultrasound devices can be widely deployed compared to professional hospital ultrasound machines. However, their images suffer from compound degradation that can mislead clinical judgment. Motivated by this observation, mapping handheld low-quality (LQ) to hospital high-quality (HQ) images has been considered a valuable research question. Conventionally, the mapping requires pixel-aligned LQ-HQ pairs. This requirement is unsatisfactory in practical scenarios because real scans at different times are never pixel-aligned. This paper addresses the challenge with a two-stage framework. The first stage generates pixel-aligned LQ-HQ datasets, and the second stage trains an enhancement model that improves LQ images. The first stage trains a cycle-consistent style-transfer model on unaligned real LQ-HQ pairs to learn a HQ-to-LQ model. Then, the model transforms real HQ images into pixel-aligned LQ images. Based on the dataset generated by the first stage, the second stage uses the Dual Degradation-Guided (DDG) Low-Rank Adaptation (LoRA) method to fine-tune an LQ-to-HQ model based on aligned pairs. In this stage, the model is based on the well known PiSA-SR framework but…
PDF arXiv
arXiv cs.LGSep 28
Cyclostationary Phase Conditioning for Medical Time Series Diffusion
Samuel Ruiperez-Campillo, Michele Copetti, Jorge da Silva Goncalves, Sonia Laguna, Thomas Hofmann +1
Many physiological time series, such as cardiac and brain recordings, exhibit cyclostationarity: their statistics vary periodically with an underlying cycle phase. Corruption from motion, poor contact, and physiological interference obscures morphology needed for diagnosis, making signal restoration essential. Existing diffusion approaches condition on corrupted observations alone and must learn cyclic structure implicitly. We instead propose two inductive biases which encode cyclostationarity: a shift-covariant wavelet representation and dense per-sample phase conditioning inferred from the corrupted input. We further introduce a training-free cyclostationarity index that quantifies phase structure and predicts when phase conditioning will help. Finally, we propose antithetic coupling of reverse trajectories to reduce sampling variance while achieving comparable performance with fivefold fewer network evaluations. Across modalities, our results show that explicitly encoding measurable cyclic structure improves physiological time-series restoration.
PDF arXiv

Papers

Topics in this field

image segmentation · volumetric · medical image403 papers50 this week
radiology report generation · medical vision language · vision language models127 papers33 this week
clinical reasoning · question answering · language models205 papers25 this week
eeg foundation models · electroencephalography eeg · eeg foundation155 papers23 this week
patient history · clinical data · health records109 papers22 this week
electrocardiogram ecg · electrocardiogram · ecgs145 papers15 this week

Active contributors · 90 days

Activity · 12 weeks

Recent papers

All papers in Research

arXiv q-bio.QMSep 28
Uncertainty Quantification in Cardiac Model Personalisation from Ultrafast Ultrasound
Camilla Ferrario, Maelys Venet, Olivier Villemain, Maxime Sermesant
Cardiac model personalisation requires inferring mechanical parameters that are not directly measurable in vivo. Ultrafast ultrasound shear wave elastography (SWE) enables non-invasive tracking of myocardial stiffness dynamics over the cardiac cycle, providing a target for personalisation. However, mapping these observations to subject specific model parameters remains ill-posed, as multiple parameter sets can reproduce the same stiffness dynamics. We formulate SWE-informed personalisation as a statistical inference problem using simulation-based inference (SBI). Using a subject-adapted 0D cardiovascular model and neural posterior estimation, we estimate model-conditional posterior distributions over active stiffness scale k0, contraction rate kATP, and relaxation rate kSR, conditioned on SWE-derived curve features and subject specific context. Among six healthy volunteers, four passed objective prior-support diagnostics and were retained for quantitative posterior analysis. Curve-level RMSE against the observed SWE target decreased from 12.61 $\pm$ 5.55 kPa for the prior predictive median to 1.14 $\pm$ 0.38 kPa for the posterior predictive median, an 89.7 $\pm$ 4.2% reduction.…
PDF arXiv
arXiv cs.CVSep 28
From UNI2-h to ConvNeXt-T: Lightweight Nuclei Instance Segmentation via Knowledge Distillation
Wenyan Li
Nuclei instance segmentation is a core task in digital pathology, yet high-accuracy models rely on large vision transformer (ViT) encoders whose inference speed cannot meet real-time clinical demands. We propose a lightweight scheme that distills the UNI2-h pathology foundation model into a ConvNeXt-Tiny student (Ours-T, 34.7M parameters, 1/20 of the teacher) via output-level knowledge distillation. Ours-T achieves an mPQ of 0.519 on PanNuke (98.8% of the teacher), a zero-shot bPQ of 0.668 on MoNuSeg, and an inference speed of 634.3 img/s, requiring only 0.045 s for full-resolution 1024^2 analysis (21.8x speedup). Experiments further show that multi-scale gated convolution (MALA) yields no gain under ViT encoders, and output-level distillation alone suffices for efficient knowledge transfer.
PDF arXiv
arXiv cs.CVSep 28
CarveMix-RC: Addressing Rare-Class Imbalance Through Lesion-Aware Synthetic Augmentation for Brain Metastasis Segmentation
Md Shibly Sadique, Md Fayaz Bin Hossen, Michael L. Evans, Walia Farzana, Asfaqur Rahman +2
Accurate segmentation of post-treatment brain metastases is essential for treatment planning, longitudinal disease monitoring, and quantitative assessment of therapeutic response. The BraTS-MET 2026 Task 1 challenge introduces a clinically relevant segmentation problem involving four anatomically distinct tumor subregions: non-enhancing tumor core (NETC), surrounding non-enhancing FLAIR hyperintensity (SNFH), enhancing tumor (ET), and the resection cavity (RC). Among these, RC segmentation is particularly challenging because of its low prevalence, heterogeneous postoperative appearance, and lesion-wise evaluation protocol, leading conventional segmentation networks to prioritize dominant tumor classes during optimization. The proposed nnU-Net-based framework explicitly addresses RC segmentation through four complementary components: (i) RC-weighted Dice and Cross-Entropy optimization to alleviate class imbalance, (ii) anatomically consistent cavity augmentation to increase the diversity of postoperative cavity appearances, (iii) a residual encoder architecture for enhanced multi-scale feature learning, and (iv) lesion-aware morphological post-processing to suppress false-positive…
PDF arXiv
arXiv cs.LGSep 28
A Multimodal Autonomic Sensing Framework for Objective Assessment of Patient Responses to Dental Pulp Stimulation
Youngsun Kong, Yubin Choi, Dongjin Song, Dong-Guk Shin, I-Ping Chen +1
Patient responses to dental pulp testing, ranging from no sensation to intense pain, provide important information for assessing pulp status in endodontic diagnosis. However, pain is a subjective sensory and emotional experience that varies considerably across individuals and can be difficult to communicate. We investigated whether complementary autonomic signals could support objective assessment of responses during dental examination. Forty-nine patients underwent cold pulp testing, yielding no-response, mild-response, and intense-response conditions. The framework integrated ECG-derived skin nerve activity (SKNA) and R-R intervals (RRI), together with electrodermal activity (EDA), using temporal convolutional network encoders with attention-based mid-level fusion. Individual baseline signals and subject-level covariates, including anxiety scores and biological sex, were also incorporated. The framework achieved 80.2% balanced accuracy, 75.2% sensitivity, and 85.2% specificity for binary classification of no response versus mild or intense response. For three-class classification, it achieved 60.0% balanced accuracy and a 58.8% macro-averaged F1 score. Ablation and…
PDF arXiv
arXiv cs.CVSep 28
Style-Driven Data Synthesis and Degradation-Aware Enhancement for Ultrasound Image Restoration
Yu-Kai Wang, Chun-Xin Tan, Manh-Hung Nguyen, Ching-Chun Huang
Low-cost handheld ultrasound devices can be widely deployed compared to professional hospital ultrasound machines. However, their images suffer from compound degradation that can mislead clinical judgment. Motivated by this observation, mapping handheld low-quality (LQ) to hospital high-quality (HQ) images has been considered a valuable research question. Conventionally, the mapping requires pixel-aligned LQ-HQ pairs. This requirement is unsatisfactory in practical scenarios because real scans at different times are never pixel-aligned. This paper addresses the challenge with a two-stage framework. The first stage generates pixel-aligned LQ-HQ datasets, and the second stage trains an enhancement model that improves LQ images. The first stage trains a cycle-consistent style-transfer model on unaligned real LQ-HQ pairs to learn a HQ-to-LQ model. Then, the model transforms real HQ images into pixel-aligned LQ images. Based on the dataset generated by the first stage, the second stage uses the Dual Degradation-Guided (DDG) Low-Rank Adaptation (LoRA) method to fine-tune an LQ-to-HQ model based on aligned pairs. In this stage, the model is based on the well known PiSA-SR framework but…
PDF arXiv
arXiv cs.LGSep 28
Cyclostationary Phase Conditioning for Medical Time Series Diffusion
Samuel Ruiperez-Campillo, Michele Copetti, Jorge da Silva Goncalves, Sonia Laguna, Thomas Hofmann +1
Many physiological time series, such as cardiac and brain recordings, exhibit cyclostationarity: their statistics vary periodically with an underlying cycle phase. Corruption from motion, poor contact, and physiological interference obscures morphology needed for diagnosis, making signal restoration essential. Existing diffusion approaches condition on corrupted observations alone and must learn cyclic structure implicitly. We instead propose two inductive biases which encode cyclostationarity: a shift-covariant wavelet representation and dense per-sample phase conditioning inferred from the corrupted input. We further introduce a training-free cyclostationarity index that quantifies phase structure and predicts when phase conditioning will help. Finally, we propose antithetic coupling of reverse trajectories to reduce sampling variance while achieving comparable performance with fivefold fewer network evaluations. Across modalities, our results show that explicitly encoding measurable cyclic structure improves physiological time-series restoration.
PDF arXiv

Fields · AI · updated 12m ago

Image segmentation

Found by the topic model: image segmentation, clinical reasoning, eeg foundation models.

168papers this week−24.0% vs last week

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Open problems in Image segmentation

Lack of whole-slide image generation for histopathology1 paper raises it · 1 addresses it
Current generative models only produce small patches, but clinical labels and reports operate at the whole-slide level, limiting alignment with real-world supervision.
- BigCell: Generating Gigapixel Whole-Slide Imagesraises · addresses
Limited longitudinal multimodal reasoning benchmarks1 paper raises it · 1 addresses it
Most medical benchmarks assess reasoning over preselected evidence, not the ability to seek and integrate evidence across longitudinal clinical records and imaging.
- From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoningraises · addresses
Frozen models cannot learn from deployment experience1 paper raises it · 1 addresses it
Deployed models in medicine do not adapt to new clinical evidence or updated guidelines without retraining, which is often impractical.
- Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AIraises · addresses
Benchmark misalignment with real-world clinical use1 paper raises it · 1 addresses it
Public benchmarks often do not reflect the tasks, intents, or constraints of actual clinician queries, reducing their predictive value for deployment performance.
- Clinician use of language models diverges from how the models are evaluatedraises · addresses
Sensitivity to incidental information in clinical reasoning1 paper raises it · 1 addresses it
Models may incorporate or misattribute irrelevant details (e.g., small talk, background noise) in clinical documentation or reasoning, risking contamination.
- Large language models are vulnerable to incidental information in clinical documentation and reasoningraises · addresses

Named by an AI from these papers' abstracts.